Protein THEMIS

Thymocyte selection associated
Identifiers
Symbols	THEMIS ; C6orf190; C6orf207; GASP; SPOT; TSEPA; bA325O24.3; bA325O24.4
External IDs	OMIM: 613607 MGI: 2443552 HomoloGene: 72287 GeneCards: THEMIS Gene
Gene ontology Molecular function • protein binding Cellular component • nucleus • cytoplasm • COP9 signalosome Biological process • adaptive immune response • positive T cell selection • negative T cell selection • T cell receptor signaling pathway Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	387357	210757
Ensembl	ENSG00000172673	ENSMUSG00000049109
UniProt	Q8N1K5	Q8BGW0
RefSeq (mRNA)	NM_001010923	NM_001305663
RefSeq (protein)	NP_001010923	NP_001292592
Location (UCSC)	Chr 6: 127.71 – 127.92 Mb	Chr 10: 28.67 – 28.88 Mb
PubMed search

Protein THEMIS is a protein that in humans is encoded by the THEMIS gene.^[1][2][3]

Function

This protein plays a regulatory role in both positive and negative T cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells.^[4]

The name

THEMIS is an acronym for thymocyte-expressed-molecule. Themis is also the name of a Titan in Greek mythology who weighed the fates of humans, an apt choice since the protein is important in deciding the fate of the T cell during development.^[5]

References

1. Fu G, Vallée S, Rybakin V, McGuire MV, Ampudia J, Brockmeyer C, Salek M, Fallen PR, Hoerter JA, Munshi A, Huang YH, Hu J, Fox HS, Sauer K, Acuto O, Gascoigne NR (August 2009). "Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling". Nat. Immunol. 10 (8): 848–56. doi:10.1038/ni.1766. PMC 2757056. PMID 19597499.
2. Lesourne R, Uehara S, Lee J, Song KD, Li L, Pinkhasov J, Zhang Y, Weng NP, Wildt KF, Wang L, Bosselut R, Love PE (August 2009). "Themis, a T cell-specific protein important for late thymocyte development". Nat. Immunol. 10 (8): 840–7. doi:10.1038/ni.1768. PMC 2848698. PMID 19597498.
3. Johnson AL, Aravind L, Shulzhenko N, Morgun A, Choi SY, Crockford TL, Lambe T, Domaschenz H, Kucharska EM, Zheng L, Vinuesa CG, Lenardo MJ, Goodnow CC, Cornall RJ, Schwartz RH (August 2009). "Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection". Nat. Immunol. 10 (8): 831–9. doi:10.1038/ni.1769. PMC 2908989. PMID 19597497.
4. "Entrez Gene: thymocyte selection associated".
5. Zielinska E (2009-11-01). "Six degrees of science". The Scientist.

Further reading

• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression.". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013.
• Allen PM (2009). "Themis imposes new law and order on positive selection.". Nat. Immunol. 10 (8): 805–6. doi:10.1038/ni0809-805. PMID 19621038.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.