Proteotoxicity

Proteotoxicity is toxicity caused by proteins, usually of misfolded proteins.[1] Examples of proteotoxic proteins are the prion protein, and several proteins that when mutated result in neurodegenerative disease and produce aggregates in brain tissues, such as amyloid-beta in Alzheimer's disease and huntingtin in Huntington's disease. It is hypothesized that chaperones, proteins that assist protein folding antagonize proteotoxicity.[2]

See also

References

  1. ↑ Douglas, P. M.; Dillin, A. (2010). "Protein homeostasis and aging in neurodegeneration". The Journal of Cell Biology 190 (5): 719–729. doi:10.1083/jcb.201005144. PMC 2935559. PMID 20819932.
  2. ↑ Douglas, P. M.; Summers, D. W.; Cyr, D. M. (2009). "Molecular chaperones antagonize proteotoxicity by differentially modulating protein aggregation pathways". Prion 3 (2): 51–58. doi:10.4161/pri.3.2.8587. PMC 2712599. PMID 19421006.
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