Pseudooxynicotine oxidase

Pseudooxynicotine oxidase (EC 1.4.3.24) is an enzyme with systematic name 4-(methylamino)-1-(pyridin-3-yl)butan-1-one:oxygen oxidoreductase (methylamine releasing).^[1] This enzyme catalyses the following chemical reaction

4-(methylamino)-1-(pyridin-3-yl)butan-1-one + H₂O + O₂

\rightleftharpoons

4-oxo-4-(pyridin-3-yl)butanal + methylamine + H₂O₂

This enzyme contains one non-covalently bound FAD.

References

↑ Qiu, J., Ma, Y., Wen, Y., Chen, L., Wu, L. and Liu, W. (2012). "Functional identification of two novel genes from Pseudomonas sp. strain HZN6 involved in the catabolism of nicotine". Appl. Environ. Microbiol. 78: 2154–2160. doi:10.1128/AEM.07025-11. PMC 3302611. PMID 22267672.

External links

Pseudooxynicotine oxidase at the US National Library of Medicine Medical Subject Headings (MeSH)

CH-NH₂ oxidoreductases (EC 1.4) - primarily amino acid oxidoreductases

1.4.1: NAD/NADP acceptor	Glutamate dehydrogenase GLUD1 GLUD2 Glutamate synthase (NADPH)

1.4.3: oxygen acceptor	D-amino acid oxidase Amine oxidase (Copper-containing (Lysyl Diamine Primary-amine)) (Flavin-containing (Monoamine)))

1.4.4: disulfide acceptor	Glycine cleavage system

1.4.99: other acceptors	D-amino acid dehydrogenase Amine dehydrogenase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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