Putrescine aminotransferase

Putrescine aminotransferase
Identifiers
EC number	2.6.1.82
CAS number	98982-73-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Putrescine aminotransferase (EC 2.6.1.82, putrescine-alpha-ketoglutarate transaminase, YgjG, putrescine:alpha-ketoglutarate aminotransferase, PAT, putrescine:2-oxoglutarate aminotransferase, putrescine transaminase) is an enzyme with systematic name butane-1,4-diamine:2-oxoglutarate aminotransferase.^[1][2][3] This enzyme catalyses the following chemical reaction

putrescine + 2-oxoglutarate $\rightleftharpoons$ 1-pyrroline + L-glutamate + H₂O (overall reaction)

(1a) putrescine + 2-oxoglutarate $\rightleftharpoons$ 4-aminobutanal + L-glutamate

(1b) 4-aminobutanal $\rightleftharpoons$ 1-pyrroline + H₂O (spontaneous)

This enzyme is a pyridoxal-phosphate protein.

References

1. Prieto-Santos, M.I., Martin-Checa, J., Balaña-Fouce, R. and Garrido-Pertierra, A. (1986). "A pathway for putrescine catabolism in Escherichia coli". Biochim. Biophys. Acta 880 (2-3): 242–244. doi:10.1016/0304-4165(86)90085-1. PMID 3510672.
2. Samsonova, N.N., Smirnov, S.V., Novikova, A.E. and Ptitsyn, L.R. (2005). "Identification of Escherichia coli K12 YdcW protein as a γ-aminobutyraldehyde dehydrogenase". FEBS Lett. 579: 4107–4112. doi:10.1016/j.febslet.2005.06.038. PMID 16023116.
3. Samsonova, N.N., Smirnov, S.V., Altman, I.B. and Ptitsyn, L.R. (2003). "Molecular cloning and characterization of Escherichia coli K12 ygjG gene". BMC Microbiol. 3 (1): 2–2. PMID 12617754.

External links

• Putrescine aminotransferase at the US National Library of Medicine Medical Subject Headings (MeSH)