QRFP
| Pyroglutamylated RFamide peptide | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | QRFP ; 26RFa; P518 | ||||||||||||
| External IDs | OMIM: 609795 MGI: 3630329 HomoloGene: 52341 GeneCards: QRFP Gene | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 347148 | 227717 | |||||||||||
| Ensembl | ENSG00000188710 | ENSMUSG00000043102 | |||||||||||
| UniProt | P83859 | Q8CE23 | |||||||||||
| RefSeq (mRNA) | NM_198180 | NM_183424 | |||||||||||
| RefSeq (protein) | NP_937823 | NP_906269 | |||||||||||
| Location (UCSC) |
Chr 9: 130.89 – 130.9 Mb |
Chr 2: 31.81 – 31.81 Mb | |||||||||||
| PubMed search | |||||||||||||
RF(Arg-Phe)amide family 26 amino acid peptide, also known as P518, is a human protein.[1]
The 26-amino acid RF-amide peptide, P518 functions as a high-affinity ligand of GPR103. Both GPR103 and P518 precursor mRNA exhibited highest expression in brain.[2] The 43-amino acid QRFP peptide, a longer form of the P518 peptide is necessary to exhibit full agonistic activity with GPR103. Intravenous administration QRFP caused release of aldosterone, suggesting that QRFP and GPR103 regulate adrenal function.[3]
References
- ↑ "Entrez Gene: P518 RF(Arg-Phe)amide family 26 amino acid peptide".
- ↑ Jiang Y, Luo L, Gustafson EL, Yadav D, Laverty M, Murgolo N, Vassileva G, Zeng M, Laz TM, Behan J, Qiu P, Wang L, Wang S, Bayne M, Greene J, Monsma F, Zhang FL (July 2003). "Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155". J. Biol. Chem. 278 (30): 27652–7. doi:10.1074/jbc.M302945200. PMID 12714592.
- ↑ Fukusumi S, Yoshida H, Fujii R, Maruyama M, Komatsu H, Habata Y, Shintani Y, Hinuma S, Fujino M (November 2003). "A new peptidic ligand and its receptor regulating adrenal function in rats". J. Biol. Chem. 278 (47): 46387–95. doi:10.1074/jbc.M305270200. PMID 12960173.
External links
- "Peptide P518 Receptor". IUPHAR/BPS Guide to PHARMACOLOGY.
Further reading
- Bruzzone F, Lectez B, Tollemer H, et al. (2007). "Anatomical distribution and biochemical characterization of the novel RFamide peptide 26RFa in the human hypothalamus and spinal cord.". J. Neurochem. 99 (2): 616–27. doi:10.1111/j.1471-4159.2006.04090.x. PMID 16899066.
- Chartrel N, Bruzzone F, Dujardin C, et al. (2006). "Identification of 26RFa from frog brain: a novel hypothalamic neuropeptide with orexigenic activity in mammals". Ann. N. Y. Acad. Sci. 1040: 80–3. Bibcode:2005NYASA1040...80C. doi:10.1196/annals.1327.009. PMID 15891009.
- Thuau R, Guilhaudis L, Ségalas-Milazzo I, et al. (2005). "Structural studies on 26RFa, a novel human RFamide-related peptide with orexigenic activity.". Peptides 26 (5): 779–89. doi:10.1016/j.peptides.2005.01.006. PMID 15808908.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Chartrel N, Dujardin C, Anouar Y, et al. (2004). "Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity". Proc. Natl. Acad. Sci. U.S.A. 100 (25): 15247–52. Bibcode:2003PNAS..10015247C. doi:10.1073/pnas.2434676100. PMC 299975. PMID 14657341.
- Fukusumi S, Yoshida H, Fujii R, et al. (2004). "A new peptidic ligand and its receptor regulating adrenal function in rats.". J. Biol. Chem. 278 (47): 46387–95. doi:10.1074/jbc.M305270200. PMID 12960173.
- Jiang Y, Luo L, Gustafson EL, et al. (2003). "Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155.". J. Biol. Chem. 278 (30): 27652–7. doi:10.1074/jbc.M302945200. PMID 12714592.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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