Quinazolinone

4-Quinazolinone

Names
IUPAC name Quinazolin-4(3H)-one
Other names 4(3H)-Quinazolinone; 4(1H)-Quinazolinone; 3,4-Dihydroquinazolin-4-one; 4(3H)-Quinazolone; 4-Hydroxyquinazoline; 4-Oxo-3,4-dihydroquinazoline; 4-Oxoquinazoline; 4-Quinazolinol; 4-Quinazolinone; 4-Quinazolone
Identifiers
CAS Number	491-36-1
ChEMBL	ChEMBL266540
ChemSpider	56797
Jmol 3D model	Interactive image
PubChem	63112
InChI InChI=1S/C8H6N2O/c11-8-6-3-1-2-4-7(6)9-5-10-8/h1-5H,(H,9,10,11)
SMILES O=C2\N=C/Nc1ccccc12
Properties
Chemical formula	C8H6N2O
Molar mass	146.15 g·mol^−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Quinazolinone is a heterocyclic chemical compound. There are two structural isomers, 2-quinazolinone and 4-quinazolinone, with the 4-isomer being the more common.

• 

  2-Quinazolinone

• 

  4-Quinazolinone

Derivatives

Quinazolinones are also a class of drugs which function as hypnotic/sedatives that contain a 4-quinazolinone core. Their use has also been proposed in the treatment of cancer.^[1]

See also

• Idelalisib (Zydelig)
• Methaqualone (Quaalude)

References

1. Chen K, Wang K, Kirichian AM, et al. (December 2006). "In silico design, synthesis, and biological evaluation of radioiodinated quinazolinone derivatives for alkaline phosphatase-mediated cancer diagnosis and therapy". Mol. Cancer Ther. 5 (12): 3001–13. doi:10.1158/1535-7163.MCT-06-0465. PMID 17172404.