RAB11FIP3

RAB11 family interacting protein 3 (class II)
PDB rendering based on 2d7c.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2D7C​, 2HV8​, 4D0M​
Identifiers
Symbols	RAB11FIP3 ; CART1; Rab11-FIP3
External IDs	OMIM: 608738 MGI: 2444431 HomoloGene: 49396 GeneCards: RAB11FIP3 Gene
EC number	2.7.4.6
Gene ontology Molecular function • calcium ion binding • protein binding • Rab GTPase binding • ADP-ribosylation factor binding • protein homodimerization activity Cellular component • nucleoplasm • endosome • centrosome • microtubule organizing center • cytosol • endocytic vesicle • midbody • cleavage furrow • intracellular membrane-bounded organelle • intercellular bridge • recycling endosome • recycling endosome membrane Biological process • cytokinesis • organelle organization • vesicle-mediated transport • endocytic recycling • negative regulation of adiponectin secretion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9727	215445
Ensembl	ENSG00000090565	ENSMUSG00000037098
UniProt	O75154	Q8CHD8
RefSeq (mRNA)	NM_001142272	NM_001162868
RefSeq (protein)	NP_001135744	NP_001156340
Location (UCSC)	Chr 16: 0.43 – 0.52 Mb	Chr 17: 25.99 – 26.07 Mb
PubMed search

Rab11 family-interacting protein 3 is a protein that in humans is encoded by the RAB11FIP3 gene.^[1][2][3]

Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP3 is one of many proteins that interact with and regulate Rab GTPases (Hales et al., 2001).[supplied by OMIM]^[3]

Interactions

RAB11FIP3 has been shown to interact with RAB11A.^[4]

References

1. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
2. Prekeris R, Davies JM, Scheller RH (October 2001). "Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins". J Biol Chem 276 (42): 38966–70. doi:10.1074/jbc.M106133200. PMID 11481332.
3. "Entrez Gene: RAB11FIP3 RAB11 family interacting protein 3 (class II)".
4. Hales, C M; Griner R; Hobdy-Henderson K C; Dorn M C; Hardy D; Kumar R; Navarre J; Chan E K; Lapierre L A; Goldenring J R (October 2001). "Identification and characterization of a family of Rab11-interacting proteins". J. Biol. Chem. (United States) 276 (42): 39067–75. doi:10.1074/jbc.M104831200. ISSN 0021-9258. PMID 11495908.

Further reading

• Shin OH, Ross AH, Mihai I, Exton JH (2000). "Identification of arfophilin, a target protein for GTP-bound class II ADP-ribosylation factors". J. Biol. Chem. 274 (51): 36609–15. doi:10.1074/jbc.274.51.36609. PMID 10593962.
• Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
• Hales CM, Griner R, Hobdy-Henderson KC, et al. (2001). "Identification and characterization of a family of Rab11-interacting proteins". J. Biol. Chem. 276 (42): 39067–75. doi:10.1074/jbc.M104831200. PMID 11495908.
• Shin OH, Couvillon AD, Exton JH (2001). "Arfophilin is a common target of both class II and class III ADP-ribosylation factors". Biochemistry 40 (36): 10846–52. doi:10.1021/bi0107391. PMID 11535061.
• Yang CS, Weiner H (2002). "Yeast two-hybrid screening identifies binding partners of human Tom34 that have ATPase activity and form a complex with Tom34 in the cytosol". Arch. Biochem. Biophys. 400 (1): 105–10. doi:10.1006/abbi.2002.2778. PMID 11913976.
• Wallace DM, Lindsay AJ, Hendrick AG, McCaffrey MW (2003). "Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells". Biochem. Biophys. Res. Commun. 299 (5): 770–9. doi:10.1016/S0006-291X(02)02720-1. PMID 12470645.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Behrends U, Schneider I, Rössler S, et al. (2003). "Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries". Int. J. Cancer 106 (2): 244–51. doi:10.1002/ijc.11208. PMID 12800201.
• Horgan CP, Walsh M, Zurawski TH, McCaffrey MW (2004). "Rab11-FIP3 localises to a Rab11-positive pericentrosomal compartment during interphase and to the cleavage furrow during cytokinesis". Biochem. Biophys. Res. Commun. 319 (1): 83–94. doi:10.1016/j.bbrc.2004.04.157. PMID 15158446.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wilson GM, Fielding AB, Simon GC, et al. (2005). "The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis". Mol. Biol. Cell 16 (2): 849–60. doi:10.1091/mbc.E04-10-0927. PMC 545916. PMID 15601896.
• Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16". Nature 432 (7020): 988–94. doi:10.1038/nature03187. PMID 15616553.
• Shiba T, Koga H, Shin HW, et al. (2007). "Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1". Proc. Natl. Acad. Sci. U.S.A. 103 (42): 15416–21. doi:10.1073/pnas.0605357103. PMC 1622838. PMID 17030804.
• Horgan CP, Oleksy A, Zhdanov AV, et al. (2007). "Rab11-FIP3 is critical for the structural integrity of the endosomal recycling compartment". Traffic 8 (4): 414–30. doi:10.1111/j.1600-0854.2007.00543.x. PMID 17394487.
• Schonteich E, Pilli M, Simon GC, et al. (2007). "Molecular characterization of Rab11-FIP3 binding to ARF GTPases". Eur. J. Cell Biol. 86 (8): 417–31. doi:10.1016/j.ejcb.2007.05.004. PMID 17628206.