RAB17

RAB17, member RAS oncogene family
Identifiers
Symbols	RAB17 ; FLJ12538
External IDs	OMIM: 602206 MGI: 104640 HomoloGene: 7502 GeneCards: RAB17 Gene
Gene ontology Molecular function • GTPase activity • protein binding • GTP binding • GDP binding Cellular component • intracellular • early endosome • plasma membrane • basolateral plasma membrane • apical plasma membrane • endocytic vesicle • dendrite • melanosome • neuronal cell body • recycling endosome • recycling endosome membrane • extracellular exosome Biological process • immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor • intracellular protein transport • regulation of endocytosis • establishment of melanosome localization • melanosome transport • endocytic recycling • Rab protein signal transduction • cilium assembly • transcytosis • filopodium assembly • regulation of dendrite development • regulation of filopodium assembly • regulation of synapse assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	64284	19329
Ensembl	ENSG00000124839	ENSMUSG00000026304
UniProt	Q9H0T7	P35292
RefSeq (mRNA)	NM_022449	NM_001159725
RefSeq (protein)	NP_071894	NP_001153197
Location (UCSC)	Chr 2: 237.57 – 237.6 Mb	Chr 1: 90.96 – 90.97 Mb
PubMed search

Ras-related protein Rab-17 is a protein that in humans is encoded by the RAB17 gene.^[1][2]

In melanocytic cells RAB17 gene expression may be regulated by MITF.^[3]

References

1. Hunziker W, Peters PJ (Jul 1998). "Rab17 localizes to recycling endosomes and regulates receptor-mediated transcytosis in epithelial cells". J Biol Chem 273 (25): 15734–41. doi:10.1074/jbc.273.25.15734. PMID 9624171.
2. "Entrez Gene: RAB17 RAB17, member RAS oncogene family".
3. Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Lütcke A, Jansson S, Parton RG, et al. (1993). "Rab17, a novel small GTPase, is specific for epithelial cells and is induced during cell polarization.". J. Cell Biol. 121 (3): 553–64. doi:10.1083/jcb.121.3.553. PMC 2119572. PMID 8486736.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Bucci C, Chiariello M, Lattero D, et al. (1999). "Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1).". Biochem. Biophys. Res. Commun. 258 (3): 657–62. doi:10.1006/bbrc.1999.0651. PMID 10329441.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.