RAB21

RAB21, member RAS oncogene family
PDB rendering based on 1yzt.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1YZT​, 1YZU​, 1Z08​, 1Z0I​, 2OT3​
Identifiers
Symbols	RAB21 ; KIAA0118
External IDs	OMIM: 612398 MGI: 894308 HomoloGene: 8991 GeneCards: RAB21 Gene
Gene ontology Molecular function • GTPase activity • protein binding • GTP binding • GDP binding Cellular component • endosome • early endosome • endoplasmic reticulum membrane • trans-Golgi network • focal adhesion • cytoplasmic side of plasma membrane • vesicle membrane • cytoplasmic vesicle membrane • cleavage furrow • Golgi cisterna membrane • neuron projection • extracellular exosome • cytoplasmic side of early endosome membrane Biological process • intracellular protein transport • anterograde axon cargo transport • regulation of exocytosis • regulation of axon extension • Rab protein signal transduction • positive regulation of receptor-mediated endocytosis • positive regulation of dendrite morphogenesis • positive regulation of early endosome to late endosome transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23011	216344
Ensembl	ENSG00000080371	ENSMUSG00000020132
UniProt	Q9UL25	P35282
RefSeq (mRNA)	NM_014999	NM_024454
RefSeq (protein)	NP_055814	NP_077774
Location (UCSC)	Chr 12: 71.75 – 71.8 Mb	Chr 10: 115.29 – 115.32 Mb
PubMed search

Ras-related protein Rab-21 is a protein that in humans is encoded by the RAB21 gene.^[1][2][3][4]

References

1. Opdam FJ, Kamps G, Croes H, van Bokhoven H, Ginsel LA, Fransen JA (Oct 2000). "Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21 is an apically located GTP-binding protein in polarised intestinal epithelial cells". Eur J Cell Biol 79 (5): 308–16. doi:10.1078/S0171-9335(04)70034-5. PMID 10887961.
2. Pereira-Leal JB, Seabra MC (Nov 2001). "Evolution of the Rab family of small GTP-binding proteins". J Mol Biol 313 (4): 889–901. doi:10.1006/jmbi.2001.5072. PMID 11697911.
3. Pellinen T, Arjonen A, Vuoriluoto K, Kallio K, Fransen JA, Ivaska J (Jun 2006). "Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins". J Cell Biol 173 (5): 767–80. doi:10.1083/jcb.200509019. PMC 2063892. PMID 16754960.
4. "Entrez Gene: RAB21 RAB21, member RAS oncogene family".

Further reading

• Nagase T, Miyajima N, Tanaka A, et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
• Bao S, Zhu J, Garvey WT (1999). "Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects". Horm. Metab. Res. 30 (11): 656–62. doi:10.1055/s-2007-978953. PMID 9918381.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.