RAB22A

RAB22A, member RAS oncogene family
PDB rendering based on 1yvd.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1yvd​, 1z0j​
Identifiers
Symbols	RAB22A ; MGC16770
External IDs	OMIM: 612966 MGI: 105072 HomoloGene: 10782 GeneCards: RAB22A Gene
Gene ontology Molecular function • GTPase activity • protein binding • GTP binding • GDP binding Cellular component • ruffle • early endosome • plasma membrane • endosome membrane • actin cytoskeleton • phagocytic vesicle membrane • phagocytic vesicle • extracellular exosome Biological process • intracellular protein transport • endocytosis • endosome organization • Rab protein signal transduction • regulation of vesicle size Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	57403	19334
Ensembl	ENSG00000124209	ENSMUSG00000027519
UniProt	Q9UL26	P35285
RefSeq (mRNA)	NM_020673	NM_024436
RefSeq (protein)	NP_065724	NP_077756
Location (UCSC)	Chr 20: 58.31 – 58.37 Mb	Chr 2: 173.66 – 173.71 Mb
PubMed search

Ras-related protein Rab-22A is a protein that in humans is encoded by the RAB22A gene.^[1]

The protein encoded by this gene is a member of the RAB family of small GTPases. The GTP-bound form of the encoded protein has been shown to interact with early-endosomal antigen 1, and may be involved in the trafficking of and interaction between endosomal compartments.^[1]

References

1. "Entrez Gene: RAB22A RAB22A, member RAS oncogene family".

Further reading

• Bao S, Zhu J, Garvey WT (1999). "Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects". Horm. Metab. Res. 30 (11): 656–662. doi:10.1055/s-2007-978953. PMID 9918381.
• Bucci C, Chiariello M, Lattero D, et al. (1999). "Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1)". Biochem. Biophys. Res. Commun. 258 (3): 657–662. doi:10.1006/bbrc.1999.0651. PMID 10329441.
• Opdam FJ, Kamps G, Croes H, et al. (2000). "Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21 is an apically located GTP-binding protein in polarised intestinal epithelial cells". Eur. J. Cell Biol. 79 (5): 308–316. doi:10.1078/S0171-9335(04)70034-5. PMID 10887961.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–871. doi:10.1038/414865a. PMID 11780052.
• Kauppi M, Simonsen A, Bremnes B, et al. (2002). "The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking". J. Cell. Sci. 115 (Pt 5): 899–911. PMID 11870209.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Seet LF, Liu N, Hanson BJ, Hong W (2004). "Endofin recruits TOM1 to endosomes". J. Biol. Chem. 279 (6): 4670–4679. doi:10.1074/jbc.M311228200. PMID 14613930.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Weigert R, Yeung AC, Li J, Donaldson JG (2005). "Rab22a regulates the recycling of membrane proteins internalized independently of clathrin". Mol. Biol. Cell 15 (8): 3758–3770. doi:10.1091/mbc.E04-04-0342. PMC 491835. PMID 15181155.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Mesa R, Magadán J, Barbieri A, et al. (2005). "Overexpression of Rab22a hampers the transport between endosomes and the Golgi apparatus". Exp. Cell Res. 304 (2): 339–353. doi:10.1016/j.yexcr.2004.11.017. PMID 15748882.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science 307 (5715): 1621–1625. doi:10.1126/science.1105776. PMID 15761153.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514.
• Magadán JG, Barbieri MA, Mesa R, et al. (2006). "Rab22a regulates the sorting of transferrin to recycling endosomes". Mol. Cell. Biol. 26 (7): 2595–2614. doi:10.1128/MCB.26.7.2595-2614.2006. PMC 1430328. PMID 16537905.