RAB33B

RAB33B, member RAS oncogene family
PDB rendering based on 1z06.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1z06​, 2g77​
Identifiers
Symbols	RAB33B ; SMC2
External IDs	OMIM: 605950 MGI: 1330805 HomoloGene: 9642 GeneCards: RAB33B Gene
Gene ontology Molecular function • GTPase activity • protein binding • GTP binding Cellular component • Golgi membrane • Golgi apparatus • Golgi lumen • extracellular exosome Biological process • protein targeting to Golgi • regulation of cell growth • intra-Golgi vesicle-mediated transport • autophagy • Rab protein signal transduction • skeletal system morphogenesis • regulation of epithelial cell proliferation • regulation of Golgi organization • negative regulation of constitutive secretory pathway • regulation of retrograde vesicle-mediated transport, Golgi to ER • regulation of autophagosome assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	83452	19338
Ensembl	ENSG00000172007	ENSMUSG00000027739
UniProt	Q9H082	O35963
RefSeq (mRNA)	NM_031296	NM_016858
RefSeq (protein)	NP_112586	NP_058554
Location (UCSC)	Chr 4: 139.45 – 139.48 Mb	Chr 3: 51.48 – 51.5 Mb
PubMed search

Ras-related protein Rab-33B is a protein that in humans is encoded by the RAB33B gene.^[1]

Mutations in this gene have been associated to cases of Dyggve-Melchior-Clausen syndrome.^[2]

References

1. Template:Cite web RAB33B, member RAS oncogene family
2. Alshammari MJ, Al-Otaibi L, Alkuraya FS (May 2012). "Mutation in RAB33B, which encodes a regulator of retrograde Golgi transport, defines a second Dyggve-Melchior-Clausen locus". J Med Genet 49 (7): 455–61. doi:10.1136/jmedgenet-2011-100666. PMID 22652534.

Further reading

• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Valsdottir R, Hashimoto H, Ashman K, et al. (2001). "Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER.". FEBS Lett. 508 (2): 201–9. doi:10.1016/S0014-5793(01)02993-3. PMID 11718716.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Zheng JY, Koda T, Fujiwara T, et al. (1998). "A novel Rab GTPase, Rab33B, is ubiquitously expressed and localized to the medial Golgi cisternae.". J. Cell. Sci. 111 (8): 1061–9. PMID 9512502.