RAB35

RAB35, member RAS oncogene family
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3TW8​
Identifiers
Symbols	RAB35 ; H-ray; RAB1C; RAY
External IDs	OMIM: 604199 MGI: 1924657 HomoloGene: 21361 GeneCards: RAB35 Gene
Gene ontology Molecular function • GTPase activity • protein binding • GTP binding • phosphatidylinositol-4,5-bisphosphate binding • GDP binding Cellular component • Golgi membrane • mitochondrion • endoplasmic reticulum membrane • plasma membrane • coated pit • endosome membrane • cell projection membrane • melanosome • intercellular bridge • clathrin-coated endocytic vesicle • extracellular exosome Biological process • cytokinesis • intracellular protein transport • ER to Golgi vesicle-mediated transport • protein localization • endosomal transport • antigen processing and presentation • neuron projection development • endocytic recycling • Rab protein signal transduction • protein localization to endosome • plasma membrane to endosome transport • cellular response to nerve growth factor stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11021	77407
Ensembl	ENSG00000111737	ENSMUSG00000029518
UniProt	Q15286	Q6PHN9
RefSeq (mRNA)	NM_001167606	NM_198163
RefSeq (protein)	NP_001161078	NP_937806
Location (UCSC)	Chr 12: 120.1 – 120.12 Mb	Chr 5: 115.63 – 115.65 Mb
PubMed search

Ras-related protein Rab-35 is a protein that in humans is encoded by the RAB35 gene.^[1] This GTPase participates in the traffic of recycling endosomes toward the plasma membrane,^[2]

References

1. "Entrez Gene: RAB35 RAB35, member RAS oncogene family".
2. Kouranti I, Sachse M, Arouche N, Goud B, Echard A (Sep 2006). "Rab35 regulates an endocytic recycling pathway essential for the terminal steps of cytokinesis". Current Biology 16 (17): 1719–25. doi:10.1016/j.cub.2006.07.020. PMID 16950109.

Further reading

• Chi A, Valencia JC, Hu ZZ, Watabe H, Yamaguchi H, Mangini NJ, Huang H, Canfield VA, Cheng KC, Yang F, Abe R, Yamagishi S, Shabanowitz J, Hearing VJ, Wu C, Appella E, Hunt DF (Nov 2006). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". Journal of Proteome Research 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.
• Kouranti I, Sachse M, Arouche N, Goud B, Echard A (Sep 2006). "Rab35 regulates an endocytic recycling pathway essential for the terminal steps of cytokinesis". Current Biology 16 (17): 1719–25. doi:10.1016/j.cub.2006.07.020. PMID 16950109.
• Abe Y, Takeuchi T, Imai Y, Murase R, Kamei Y, Fujibuchi T, Matsumoto S, Ueda N, Ogasawara M, Shigemoto K, Kito K (May 2006). "A Small Ras-like protein Ray/Rab1c modulates the p53-regulating activity of PRPK". Biochemical and Biophysical Research Communications 344 (1): 377–85. doi:10.1016/j.bbrc.2006.03.071. PMID 16600182.
• Zhu AX, Zhao Y, Flier JS (Dec 1994). "Molecular cloning of two small GTP-binding proteins from human skeletal muscle". Biochemical and Biophysical Research Communications 205 (3): 1875–82. doi:10.1006/bbrc.1994.2889. PMID 7811277.