RAB38

RAB38, member RAS oncogene family
Identifiers
Symbols	RAB38 ; NY-MEL-1; rrGTPbp
External IDs	OMIM: 606281 MGI: 1919683 HomoloGene: 21353 GeneCards: RAB38 Gene
Gene ontology Molecular function • GTPase activity • protein binding • GTP binding • GTP-dependent protein binding • AP-2 adaptor complex binding • AP-1 adaptor complex binding • AP-3 adaptor complex binding • BLOC-2 complex binding Cellular component • early endosome • endoplasmic reticulum • trans-Golgi network • cytosol • plasma membrane • membrane • phagocytic vesicle membrane • early endosome lumen • melanosome • phagocytic vesicle Biological process • intracellular protein transport • small GTPase mediated signal transduction • protein transport • Rab protein signal transduction • endosome to melanosome transport • platelet dense granule organization • protein localization to membrane • phagosome acidification • melanosome assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23682	72433
Ensembl	ENSG00000123892	ENSMUSG00000030559
UniProt	P57729	Q8QZZ8
RefSeq (mRNA)	NM_022337	NM_028238
RefSeq (protein)	NP_071732	NP_082514
Location (UCSC)	Chr 11: 88.11 – 88.18 Mb	Chr 7: 88.43 – 88.49 Mb
PubMed search

Ras-related protein Rab-38 is a protein that in humans is encoded by the RAB38 gene.^[1][2]

In melanocytic cells RAB38 gene expression may be regulated by MITF.^[3]

References

1. Jager D, Stockert E, Jager E, Gure AO, Scanlan MJ, Knuth A, Old LJ, Chen YT (Aug 2000). "Serological cloning of a melanocyte rab guanosine 5'-triphosphate-binding protein and a chromosome condensation protein from a melanoma complementary DNA library". Cancer Res 60 (13): 3584–91. PMID 10910072.
2. "Entrez Gene: RAB38 RAB38, member RAS oncogene family".
3. Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

Further reading

• Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Suzuki T, Miyamura Y, Inagaki K, Tomita Y (2004). "Characterization of the human RAB38 and RAB7 genes: exclusion of new major pathological loci for Japanese OCA". J. Dermatol. Sci. 32 (2): 131–6. doi:10.1016/S0923-1811(03)00071-9. PMID 12850305.
• Basrur V, Yang F, Kushimoto T, et al. (2003). "Proteomic analysis of early melanosomes: identification of novel melanosomal proteins". J. Proteome Res. 2 (1): 69–79. doi:10.1021/pr025562r. PMID 12643545.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Osanai K, Iguchi M, Takahashi K, et al. (2001). "Expression and Localization of a Novel Rab Small G Protein (Rab38) in the Rat Lung". Am. J. Pathol. 158 (5): 1665–75. doi:10.1016/S0002-9440(10)64122-3. PMC 1891947. PMID 11337364.