RAB3B

RAB3B, member RAS oncogene family
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3DZ8​
Identifiers
Symbol	RAB3B
External IDs	OMIM: 179510 MGI: 1917158 HomoloGene: 2149 GeneCards: RAB3B Gene
Gene ontology Molecular function • GTPase activity • protein binding • GTP binding • GDP binding • myosin V binding Cellular component • cytoplasm • endosome • cytosol • plasma membrane • synaptic vesicle • secretory granule membrane • vesicle • perinuclear region of cytoplasm • extracellular exosome Biological process • intracellular protein transport • vesicle docking involved in exocytosis • protein secretion • synaptic vesicle exocytosis • regulation of exocytosis • peptidyl-cysteine methylation • antigen processing and presentation • Rab protein signal transduction • positive regulation of dopamine uptake involved in synaptic transmission • protein localization to plasma membrane • regulation of vesicle size Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5865	69908
Ensembl	ENSG00000169213	ENSMUSG00000003411
UniProt	P20337	Q9CZT8
RefSeq (mRNA)	NM_002867	NM_023537
RefSeq (protein)	NP_002858	NP_076026
Location (UCSC)	Chr 1: 51.91 – 51.99 Mb	Chr 4: 108.88 – 108.94 Mb
PubMed search

Ras-related protein Rab-3B is a protein that in humans is encoded by the RAB3B gene.^[1]

Interactions

RAB3B has been shown to interact with RPH3A.^[2][3]

References

1. "Entrez Gene: RAB3B RAB3B, member RAS oncogene family".
2. Fukuda, Mitsunori (Apr 2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". J. Biol. Chem. (United States) 278 (17): 15373–80. doi:10.1074/jbc.M212341200. ISSN 0021-9258. PMID 12578829.
3. Weber, E; Jilling T; Kirk K L (Mar 1996). "Distinct functional properties of Rab3A and Rab3B in PC12 neuroendocrine cells". J. Biol. Chem. (UNITED STATES) 271 (12): 6963–71. doi:10.1074/jbc.271.12.6963. ISSN 0021-9258. PMID 8636125.

Further reading

• Rousseau-Merck MF, Zahraoui A, Touchot N, et al. (1991). "Chromosome assignment of four RAS-related RAB genes.". Hum. Genet. 86 (4): 350–4. doi:10.1007/BF00201831. PMID 1999336.
• Zahraoui A, Touchot N, Chardin P, Tavitian A (1989). "The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion.". J. Biol. Chem. 264 (21): 12394–401. PMID 2501306.
• Weber E, Berta G, Tousson A, et al. (1994). "Expression and polarized targeting of a rab3 isoform in epithelial cells.". J. Cell Biol. 125 (3): 583–94. doi:10.1083/jcb.125.3.583. PMC 2119989. PMID 8175882.
• Weber E, Jilling T, Kirk KL (1996). "Distinct functional properties of Rab3A and Rab3B in PC12 neuroendocrine cells.". J. Biol. Chem. 271 (12): 6963–71. doi:10.1074/jbc.271.12.6963. PMID 8636125.
• Regazzi R, Ravazzola M, Iezzi M, et al. (1997). "Expression, localization and functional role of small GTPases of the Rab3 family in insulin-secreting cells.". J. Cell. Sci. 109 (9): 2265–73. PMID 8886977.
• Sidhu RS, Bhullar RP (2002). "Rab3B in human platelet is membrane bound and interacts with Ca(2+)/calmodulin.". Biochem. Biophys. Res. Commun. 289 (5): 1039–43. doi:10.1006/bbrc.2001.6113. PMID 11741295.
• van IJzendoorn SC, Tuvim MJ, Weimbs T, et al. (2002). "Direct interaction between Rab3b and the polymeric immunoglobulin receptor controls ligand-stimulated transcytosis in epithelial cells.". Dev. Cell 2 (2): 219–28. doi:10.1016/S1534-5807(02)00115-6. PMID 11832247.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Fukuda M (2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2.". J. Biol. Chem. 278 (17): 15373–80. doi:10.1074/jbc.M212341200. PMID 12578829.
• Yamamoto Y, Nishimura N, Morimoto S, et al. (2003). "Distinct roles of Rab3B and Rab13 in the polarized transport of apical, basolateral, and tight junctional membrane proteins to the plasma membrane.". Biochem. Biophys. Res. Commun. 308 (2): 270–5. doi:10.1016/S0006-291X(03)01358-5. PMID 12901864.
• Matsumoto M, Miki T, Shibasaki T, et al. (2004). "Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells.". Proc. Natl. Acad. Sci. U.S.A. 101 (22): 8313–8. doi:10.1073/pnas.0306709101. PMC 420391. PMID 15159548.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.