RAB6C

RAB6C, member RAS oncogene family
PDB rendering based on 1yzq.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1yzq​
Identifiers
Symbols	RAB6C ; WTH3
External IDs	OMIM: 612909 HomoloGene: 108091 GeneCards: RAB6C Gene
Gene ontology Molecular function • GTPase activity • GTP binding Cellular component • intracellular • nucleus • Golgi apparatus • centrosome Biological process • intracellular protein transport • retrograde vesicle-mediated transport, Golgi to ER • intra-Golgi vesicle-mediated transport • small GTPase mediated signal transduction • regulation of centrosome duplication • cell cycle process • Rab protein signal transduction • retrograde transport, endosome to Golgi • response to drug Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	84084	n/a
Ensembl	ENSG00000222014	n/a
UniProt	Q9H0N0	n/a
RefSeq (mRNA)	NM_032144	n/a
RefSeq (protein)	NP_115520	n/a
Location (UCSC)	Chr 2: 129.98 – 129.98 Mb	n/a
PubMed search		n/a

Ras-related protein Rab-6C is a protein that in humans is encoded by the RAB6C gene.^[1][2][3]

References

1. Shan J, Mason JM, Yuan L, Barcia M, Porti D, Calabro A, Budman D, Vinciguerra V, Xu H (Dec 2000). "Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells". Gene 257 (1): 67–75. doi:10.1016/S0378-1119(00)00395-4. PMID 11054569.
2. Tian K, Wang Y, Xu H (May 2007). "WTH3 is a direct target of the p53 protein". Br J Cancer 96 (10): 1579–86. doi:10.1038/sj.bjc.6603724. PMC 2359938. PMID 17426708.
3. "Entrez Gene: RAB6C RAB6C, member RAS oncogene family".

Further reading

• "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Fitzgerald ML, Reed GL (1999). "Rab6 is phosphorylated in thrombin-activated platelets by a protein kinase C-dependent mechanism: effects on GTP/GDP binding and cellular distribution". Biochem. J. 342 ( Pt 2) (2): 353–60. doi:10.1042/0264-6021:3420353. PMC 1220472. PMID 10455022.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Shan J, Yuan L, Budman DR, Xu HP (2002). "WTH3, a new member of the Rab6 gene family, and multidrug resistance". Biochim. Biophys. Acta 1589 (2): 112–23. doi:10.1016/S0167-4889(02)00164-7. PMID 12007787.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Tian K, Jurukovski V, Wang XP, et al. (2005). "Epigenetic regulation of WTH3 in primary and cultured drug-resistant breast cancer cells". Cancer Res. 65 (21): 10024–31. doi:10.1158/0008-5472.CAN-05-1944. PMID 16267028.