RAET1E

Retinoic acid early transcript 1E
Identifiers
Symbols RAET1E ; LETAL; N2DL-4; NKG2DL4; RAET1E2; RL-4; ULBP4; bA350J20.7
External IDs OMIM: 609243 HomoloGene: 131086 GeneCards: RAET1E Gene
Orthologs
Species Human Mouse
Entrez 135250 n/a
Ensembl ENSG00000164520 n/a
UniProt Q8TD07 n/a
RefSeq (mRNA) NM_001243325 n/a
RefSeq (protein) NP_001230254 n/a
Location (UCSC) Chr 6:
149.88 – 149.9 Mb		 n/a
PubMed search n/a

Retinoic acid early transcript 1E (RAET1E) is a cell surface glycoprotein encoded by RAET1E gene located on the chromosome 6.[1] RAET1E is related to MHC class I molecules, but its gene maps outside the MHC locus.[1] RAET1E is composed of external α1α2 domain, transmembrane segment and C-terminal cytoplasmic tail.[1][2] RAET1E functions as a stress-induced ligand for NKG2D receptor.[2]

References

  1. 1 2 3 Radosavljevic M, Cuillerier B, Wilson MJ, Clément O, Wicker S, Gilfillan S, Beck S, Trowsdale J, Bahram S (Jan 2002). "A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3". Genomics 79 (1): 114–23. doi:10.1006/geno.2001.6673. PMID 11827464.
  2. 1 2 Jan Chalupny, N; Sutherland, Claire L; Lawrence, William A; Rein-Weston, Annie; Cosman, David (2003-05-23). "ULBP4 is a novel ligand for human NKG2D". Biochemical and Biophysical Research Communications 305 (1): 129–135. doi:10.1016/S0006-291X(03)00714-9. PMID 12732206.

Further reading

  • Chalupny NJ, Sutherland CL, Lawrence WA, Rein-Weston A, Cosman D (May 2003). "ULBP4 is a novel ligand for human NKG2D". Biochemical and Biophysical Research Communications 305 (1): 129–35. doi:10.1016/S0006-291X(03)00714-9. PMID 12732206. 
  • Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. 
  • Conejo-Garcia JR, Benencia F, Courreges MC, Khang E, Zhang L, Mohamed-Hadley A, Vinocur JM, Buckanovich RJ, Thompson CB, Levine B, Coukos G (2004). "Letal, A tumor-associated NKG2D immunoreceptor ligand, induces activation and expansion of effector immune cells". Cancer Biology & Therapy 2 (4): 446–51. doi:10.4161/cbt.2.4.479. PMID 14508119. 
  • Conejo-Garcia JR, Benencia F, Courreges MC, Gimotty PA, Khang E, Buckanovich RJ, Frauwirth KA, Zhang L, Katsaros D, Thompson CB, Levine B, Coukos G (Mar 2004). "Ovarian carcinoma expresses the NKG2D ligand Letal and promotes the survival and expansion of CD28- antitumor T cells". Cancer Research 64 (6): 2175–82. doi:10.1158/0008-5472.CAN-03-2194. PMID 15026360. 
  • Bacon L, Eagle RA, Meyer M, Easom N, Young NT, Trowsdale J (Jul 2004). "Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D". Journal of Immunology 173 (2): 1078–84. doi:10.4049/jimmunol.173.2.1078. PMID 15240696. 
  • Cao W, Xi X, Hao Z, Li W, Kong Y, Cui L, Ma C, Ba D, He W (Jun 2007). "RAET1E2, a soluble isoform of the UL16-binding protein RAET1E produced by tumor cells, inhibits NKG2D-mediated NK cytotoxicity". The Journal of Biological Chemistry 282 (26): 18922–8. doi:10.1074/jbc.M702504200. PMID 17470428. 


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