RAI2

Retinoic acid induced 2
Identifiers
Symbol	RAI2
External IDs	OMIM: 300217 MGI: 1344378 HomoloGene: 11034 GeneCards: RAI2 Gene
Gene ontology Molecular function • molecular_function • protein binding Cellular component • cellular_component Biological process • embryo development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10742	24004
Ensembl	ENSG00000131831	ENSMUSG00000043518
UniProt	Q9Y5P3	Q9QVY8
RefSeq (mRNA)	NM_001172732	NM_001103367
RefSeq (protein)	NP_001166203	NP_001096837
Location (UCSC)	Chr X: 17.8 – 17.86 Mb	Chr X: 161.72 – 161.78 Mb
PubMed search

Retinoic acid-induced protein 2 is a protein that in humans is encoded by the RAI2 gene.^[1][2][3]

Retinoic acid plays a critical role in development, cellular growth, and differentiation. The specific function of this intronless, retinoic acid-induced gene has not yet been determined; however, it has been suggested to play a role in development. Localization of this gene designates it to be a candidate for diseases such as Nance-Horan syndrome, sensorineural deafness, non-specific X-linked mental retardation, oral-facial-digital syndrome, and Fried syndrome.^[3]

References

1. Walpole SM, Hiriyana KT, Nicolaou A, Bingham EL, Durham J, Vaudin M, Ross MT, Yates JR, Sieving PA, Trump D (May 1999). "Identification and characterization of the human homologue (RAI2) of a mouse retinoic acid-induced gene in Xp22". Genomics 55 (3): 275–83. doi:10.1006/geno.1998.5667. PMID 10049581.
2. Walpole SM, Ronce N, Grayson C, Dessay B, Yates JR, Trump D, Toutain A (Jul 1999). "Exclusion of RAI2 as the causative gene for Nance-Horan syndrome". Hum Genet 104 (5): 410–1. doi:10.1007/s004390050976. PMID 10394933.
3. "Entrez Gene: RAI2 retinoic acid induced 2".

Further reading

• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.