RALBP1

RalA binding protein 1

Rendering based on PDB 2KWH​.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols RALBP1 ; RIP1; RLIP1; RLIP76
External IDs OMIM: 605801 MGI: 108466 HomoloGene: 4940 GeneCards: RALBP1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 10928 19765
Ensembl ENSG00000017797 ENSMUSG00000024096
UniProt Q15311 Q62172
RefSeq (mRNA) NM_006788 NM_001198949
RefSeq (protein) NP_006779 NP_001185878
Location (UCSC) Chr 18:
9.48 – 9.54 Mb		 Chr 17:
65.85 – 65.89 Mb
PubMed search

RalA-binding protein 1 is a protein that in humans is encoded by the RALBP1 gene.[1][2]

Interactions

RALBP1 has been shown to interact with:

References

  1. 1 2 3 Jullien-Flores V, Dorseuil O, Romero F, Letourneur F, Saragosti S, Berger R, Tavitian A, Gacon G, Camonis JH (Oct 1995). "Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity". J Biol Chem 270 (38): 22473–7. doi:10.1074/jbc.270.38.22473. PMID 7673236.
  2. ↑ "Entrez Gene: RALBP1 ralA binding protein 1".
  3. ↑ Rossé C, L'Hoste S, Offner N, Picard A, Camonis J (Aug 2003). "RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis". J. Biol. Chem. 278 (33): 30597–604. doi:10.1074/jbc.M302191200. PMID 12775724.
  4. ↑ Hu Y, Mivechi NF (May 2003). "HSF-1 interacts with Ral-binding protein 1 in a stress-responsive, multiprotein complex with HSP90 in vivo". J. Biol. Chem. 278 (19): 17299–306. doi:10.1074/jbc.M300788200. PMID 12621024.
  5. 1 2 Moskalenko S, Tong C, Rosse C, Mirey G, Formstecher E, Daviet L, Camonis J, White MA (Dec 2003). "Ral GTPases regulate exocyst assembly through dual subunit interactions". J. Biol. Chem. 278 (51): 51743–8. doi:10.1074/jbc.M308702200. PMID 14525976.
  6. ↑ Cantor SB, Urano T, Feig LA (Aug 1995). "Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases". Mol. Cell. Biol. 15 (8): 4578–84. PMC 230698. PMID 7623849.
  7. 1 2 Ikeda M, Ishida O, Hinoi T, Kishida S, Kikuchi A (Jan 1998). "Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral". J. Biol. Chem. 273 (2): 814–21. doi:10.1074/jbc.273.2.814. PMID 9422736.
  8. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Further reading

  • Awasthi S, Sharma R, Singhal SS, Zimniak P, Awasthi YC (2003). "RLIP76, a novel transporter catalyzing ATP-dependent efflux of xenobiotics". Drug Metab. Dispos. 30 (12): 1300–10. doi:10.1124/dmd.30.12.1300. PMID 12433796. 
  • Yamaguchi A, Urano T, Goi T, Feig LA (1998). "An Eps homology (EH) domain protein that binds to the Ral-GTPase target, RalBP1". J. Biol. Chem. 272 (50): 31230–4. doi:10.1074/jbc.272.50.31230. PMID 9395447. 
  • Ikeda M, Ishida O, Hinoi T, Kishida S, Kikuchi A (1998). "Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral". J. Biol. Chem. 273 (2): 814–21. doi:10.1074/jbc.273.2.814. PMID 9422736. 
  • Iouzalen N, Camonis J, Moreau J (1998). "Identification and characterization in Xenopus of XsmgGDS, a RalB binding protein". Biochem. Biophys. Res. Commun. 250 (2): 359–63. doi:10.1006/bbrc.1998.9336. PMID 9753634. 
  • Suzuki J, Yamazaki Y, Li G, Kaziro Y, Koide H, Guang L (2000). "Involvement of Ras and Ral in Chemotactic Migration of Skeletal Myoblasts". Mol. Cell. Biol. 20 (13): 4658–65. doi:10.1128/MCB.20.13.4658-4665.2000. PMC 85875. PMID 10848592. 
  • Jullien-Flores V, Mahé Y, Mirey G, Leprince C, Meunier-Bisceuil B, Sorkin A, Camonis JH (2000). "RLIP76, an effector of the GTPase Ral, interacts with the AP2 complex: involvement of the Ral pathway in receptor endocytosis". J. Cell. Sci. 113 (16): 2837–44. PMID 10910768. 
  • Awasthi S, Cheng J, Singhal SS, Saini MK, Pandya U, Pikula S, Bandorowicz-Pikula J, Singh SV, Zimniak P, Awasthi YC (2000). "Novel function of human RLIP76: ATP-dependent transport of glutathione conjugates and doxorubicin". Biochemistry 39 (31): 9327–34. doi:10.1021/bi992964c. PMID 10924126. 
  • Sharma R, Singhal SS, Cheng J, Yang Y, Sharma A, Zimniak P, Awasthi S, Awasthi YC (2001). "RLIP76 is the major ATP-dependent transporter of glutathione-conjugates and doxorubicin in human erythrocytes". Arch. Biochem. Biophys. 391 (2): 171–9. doi:10.1006/abbi.2001.2395. PMID 11437348. 
  • Singhal SS, Singhal J, Cheng J, Pikuła S, Sharma R, Zimniak P, Awasthi YC, Awasthi S (2002). "Purification and functional reconstitution of intact ral-binding Gtpase activating protein, RLIP76, in artificial liposomes". Acta Biochim. Pol. 48 (2): 551–62. PMID 11732624. 
  • Matsuzaki T, Hanai S, Kishi H, Liu Z, Bao Y, Kikuchi A, Tsuchida K, Sugino H (2002). "Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway". J. Biol. Chem. 277 (21): 19008–18. doi:10.1074/jbc.M112472200. PMID 11882656. 
  • Singhal SS, Singhal J, Sharma R, Singh SV, Zimniak P, Awasthi YC, Awasthi S (2003). "Role of RLIP76 in lung cancer doxorubicin resistance: I. The ATPase activity of RLIP76 correlates with doxorubicin and 4-hydroxynonenal resistance in lung cancer cells". Int. J. Oncol. 22 (2): 365–75. doi:10.3892/ijo.22.2.365. PMID 12527936. 
  • Awasthi S, Singhal SS, Singhal J, Cheng J, Zimniak P, Awasthi YC (2003). "Role of RLIP76 in lung cancer doxorubicin resistance: II. Doxorubicin transport in lung cancer by RLIP76". Int. J. Oncol. 22 (4): 713–20. doi:10.3892/ijo.22.4.713. PMID 12632060. 
  • Awasthi S, Singhal SS, Singhal J, Yang Y, Zimniak P, Awasthi YC (2003). "Role of RLIP76 in lung cancer doxorubicin resistance: III. Anti-RLIP76 antibodies trigger apoptosis in lung cancer cells and synergistically increase doxorubicin cytotoxicity". Int. J. Oncol. 22 (4): 721–32. doi:10.3892/ijo.22.4.721. PMID 12632061. 
  • Rossé C, L'Hoste S, Offner N, Picard A, Camonis J (2003). "RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis". J. Biol. Chem. 278 (33): 30597–604. doi:10.1074/jbc.M302191200. PMID 12775724. 
  • Moskalenko S, Tong C, Rosse C, Mirey G, Formstecher E, Daviet L, Camonis J, White MA (2004). "Ral GTPases regulate exocyst assembly through dual subunit interactions". J. Biol. Chem. 278 (51): 51743–8. doi:10.1074/jbc.M308702200. PMID 14525976. 
  • Gómez MI, Lee A, Reddy B, Muir A, Soong G, Pitt A, Cheung A, Prince A (2004). "Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1". Nat. Med. 10 (8): 842–8. doi:10.1038/nm1079. PMID 15247912. 
  • Zhang H, Zhang R, Luo Y, D'Alessio A, Pober JS, Min W (2004). "AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation". J. Biol. Chem. 279 (43): 44955–65. doi:10.1074/jbc.M407617200. PMID 15310755. 


This article is issued from Wikipedia - version of the Wednesday, October 21, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.