RANBP1

RAN binding protein 1

PDB rendering based on 1k5d.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols RANBP1 ; HTF9A
External IDs OMIM: 601180 MGI: 96269 HomoloGene: 21600 GeneCards: RANBP1 Gene
Orthologs
Species Human Mouse
Entrez 5902 19385
Ensembl ENSG00000099901 ENSMUSG00000005732
UniProt P43487 P34022
RefSeq (mRNA) NM_001278639 NM_011239
RefSeq (protein) NP_001265568 NP_035369
Location (UCSC) Chr 22:
20.12 – 20.13 Mb
Chr 16:
18.24 – 18.25 Mb
PubMed search

Ran-specific binding protein 1 is an enzyme that in humans is encoded by the RANBP1 gene.[1][2][3]

Ran/TC4-binding protein, RanBP1, interacts specifically with GTP-charged RAN. RANBP1 encodes a 23-kD protein that binds to RAN complexed with GTP but not GDP. RANBP1 does not activate GTPase activity of RAN but does markedly increase GTP hydrolysis by the RanGTPase-activating protein (RanGAP1). The RANBP1 cDNA encodes a 201-amino acid protein that is 92% similar to its mouse homolog. In both mammalian cells and in yeast, RANBP1 acts as a negative regulator of RCC1 by inhibiting RCC1-stimulated guanine nucleotide release from RAN.[3]

Interactions

RANBP1 has been shown to interact with XPO1,[4][5] KPNB1[5][6] and Ran.[5][7][8]

References

  1. Hayashi N, Yokoyama N, Seki T, Azuma Y, Ohba T, Nishimoto T (August 1995). "RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits RCC1 via Ran/TC4". Mol Gen Genet 247 (6): 661–9. doi:10.1007/BF00290397. PMID 7616957.
  2. Kehlenbach RH, Dickmanns A, Kehlenbach A, Guan T, Gerace L (July 1999). "A Role for RanBP1 in the Release of CRM1 from the Nuclear Pore Complex in a Terminal Step of Nuclear Export". J Cell Biol 145 (4): 645–57. doi:10.1083/jcb.145.4.645. PMC 2133185. PMID 10330396.
  3. 1 2 "Entrez Gene: RANBP1 RAN binding protein 1".
  4. Singh, B B; Patel H H; Roepman R; Schick D; Ferreira P A (December 1999). "The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1". J. Biol. Chem. (United States) 274 (52): 37370–8. doi:10.1074/jbc.274.52.37370. ISSN 0021-9258. PMID 10601307.
  5. 1 2 3 Plafker, K; Macara I G (May 2000). "Facilitated Nucleocytoplasmic Shuttling of the Ran Binding Protein RanBP1". Mol. Cell. Biol. (United States) 20 (10): 3510–21. doi:10.1128/MCB.20.10.3510-3521.2000. ISSN 0270-7306. PMC 85643. PMID 10779340.
  6. Yaseen, N R; Blobel G (September 1999). "GTP hydrolysis links initiation and termination of nuclear import on the nucleoporin nup358". J. Biol. Chem. (United States) 274 (37): 26493–502. doi:10.1074/jbc.274.37.26493. ISSN 0021-9258. PMID 10473610.
  7. Ren, M; Villamarin A; Shih A; Coutavas E; Moore M S; LoCurcio M; Clarke V; Oppenheim J D; D'Eustachio P; Rush M G (April 1995). "Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing". Mol. Cell. Biol. (United States) 15 (4): 2117–24. ISSN 0270-7306. PMC 230439. PMID 7891706.
  8. Steggerda, S M; Paschal B M (July 2000). "The mammalian Mog1 protein is a guanine nucleotide release factor for Ran". J. Biol. Chem. (United States) 275 (30): 23175–80. doi:10.1074/jbc.C000252200. ISSN 0021-9258. PMID 10811801.

Further reading

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