RANGAP1

Ran GTPase activating protein 1

PDB rendering based on 1z5s.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols RANGAP1 ; Fug1; RANGAP; SD
External IDs OMIM: 602362 MGI: 103071 HomoloGene: 55700 GeneCards: RANGAP1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 5905 19387
Ensembl ENSG00000100401 ENSMUSG00000022391
UniProt P46060 P46061
RefSeq (mRNA) NM_001278651 NM_001146174
RefSeq (protein) NP_001265580 NP_001139646
Location (UCSC) Chr 22:
41.25 – 41.29 Mb
Chr 15:
81.7 – 81.73 Mb
PubMed search
For more details on RanGAP proteins in non-human species, see RanGAP.

Ran GTPase-activating protein 1 is an enzyme that in humans is encoded by the RANGAP1 gene.[1][2]

Function

RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle.[2]

Interactions

RanGAP1 is a trafficking protein which helps transport other proteins from the cytoplasm to the nucleus. Small ubiqutin-related modifier needs to be associated with it before it can be localized at the nuclear pore.[3]

RANGAP1 has been shown to interact with:

References

  1. Bischoff FR, Krebber H, Kempf T, Hermes I, Ponstingl H (Apr 1995). "Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport". Proc Natl Acad Sci U S A 92 (5): 1749–53. doi:10.1073/pnas.92.5.1749. PMC 42597. PMID 7878053.
  2. 1 2 "Entrez Gene: RANGAP1 Ran GTPase activating protein 1".
  3. Hochstrasser M (2000). "Biochemistry. All in the ubiquitin family". Science 289 (5479): 563–4. doi:10.1126/science.289.5479.563. PMID 10939967.
  4. Hillig RC, Renault L, Vetter IR, Drell T, Wittinghofer A, Becker J (Jun 1999). "The crystal structure of rna1p: a new fold for a GTPase-activating protein". Mol. Cell 3 (6): 781–91. doi:10.1016/S1097-2765(01)80010-1. PMID 10394366.
  5. Becker J, Melchior F, Gerke V, Bischoff FR, Ponstingl H, Wittinghofer A (May 1995). "RNA1 encodes a GTPase-activating protein specific for Gsp1p, the Ran/TC4 homologue of Saccharomyces cerevisiae". J. Biol. Chem. 270 (20): 11860–5. doi:10.1074/jbc.270.20.11860. PMID 7744835.
  6. Bischoff FR, Klebe C, Kretschmer J, Wittinghofer A, Ponstingl H (Mar 1994). "RanGAP1 induces GTPase activity of nuclear Ras-related Ran". Proc. Natl. Acad. Sci. U.S.A. 91 (7): 2587–91. doi:10.1073/pnas.91.7.2587. PMC 43414. PMID 8146159.
  7. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D. "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  8. Tatham MH, Kim S, Yu B, Jaffray E, Song J, Zheng J, Rodriguez MS, Hay RT, Chen Y (Aug 2003). "Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation". Biochemistry 42 (33): 9959–69. doi:10.1021/bi0345283. PMID 12924945.
  9. Knipscheer P, Flotho A, Klug H, Olsen JV, van Dijk WJ, Fish A, Johnson ES, Mann M, Sixma TK, Pichler A (Aug 2008). "Ubc9 sumoylation regulates SUMO target discrimination". Mol. Cell 31 (3): 371–82. doi:10.1016/j.molcel.2008.05.022. PMID 18691969.

Further reading


This article is issued from Wikipedia - version of the Sunday, August 02, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.