RAP2B

RAP2B, member of RAS oncogene family
PDB rendering based on 1kao.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1N4P​, 1N4Q​, 1N4R​
Identifiers
Symbols	RAP2B ; MGC20484
External IDs	OMIM: 179541 MGI: 1921262 HomoloGene: 55701 GeneCards: RAP2B Gene
Gene ontology Molecular function • protein binding • GTP binding • GDP binding • protein domain specific binding Cellular component • cytosol • plasma membrane • bicellular tight junction • membrane • cell-cell contact zone • membrane raft • recycling endosome membrane • extracellular exosome Biological process • signal transduction • microvillus assembly • platelet activation • negative regulation of cell migration • positive regulation of protein autophosphorylation • Rap protein signal transduction • regulation of protein tyrosine kinase activity • platelet aggregation • establishment of endothelial intestinal barrier Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5912	74012
Ensembl	ENSG00000181467	ENSMUSG00000036894
UniProt	P61225	P61226
RefSeq (mRNA)	NM_002886	NM_028712
RefSeq (protein)	NP_002877	NP_082988
Location (UCSC)	Chr 3: 153.16 – 153.17 Mb	Chr 3: 61.36 – 61.37 Mb
PubMed search

Ras-related protein Rap-2b is a protein that in humans is encoded by the RAP2B gene.^[1][2] RAP2B belongs to the Ras-related protein family.

This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated.^[2]

References

1. Ohmstede CA, Farrell FX, Reep BR, Clemetson KJ, Lapetina EG (Oct 1990). "RAP2B: a RAS-related GTP-binding protein from platelets". Proc Natl Acad Sci U S A 87 (17): 6527–31. doi:10.1073/pnas.87.17.6527. PMC 54569. PMID 2118648.
2. "Entrez Gene: RAP2B RAP2B, member of RAS oncogene family".

Further reading

• Farrell FX, Ohmstede CA, Reep BR, Lapetina EG (1990). "cDNA sequence of a new ras-related gene (rap2b) isolated from human platelets with sequence homology to rap2". Nucleic Acids Res. 18 (14): 4281. doi:10.1093/nar/18.14.4281. PMC 331220. PMID 2115998.
• Pizon V, Chardin P, Lerosey I, et al. (1988). "Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region". Oncogene 3 (2): 201–4. PMID 3045729.
• Torti M, Ramaschi G, Sinigaglia F, et al. (1993). "Association of the low molecular weight GTP-binding protein rap2B with the cytoskeleton during platelet aggregation". Proc. Natl. Acad. Sci. U.S.A. 90 (16): 7553–7. doi:10.1073/pnas.90.16.7553. PMC 47180. PMID 8356055.
• Mollinedo F, Perez-Sala D, Gajate C, et al. (1993). "Localization of rap1 and rap2 proteins in the gelatinase-containing granules of human neutrophils". FEBS Lett. 326 (1–3): 209–14. doi:10.1016/0014-5793(93)81792-X. PMID 8391995.
• Farrell FX, Yamamoto K, Lapetina EG (1993). "Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated". Biochem. J. 289 ( Pt 2) (Pt 2): 349–55. PMC 1132174. PMID 8424780.
• Nancy V, Wolthuis RM, de Tand MF, et al. (1999). "Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2". J. Biol. Chem. 274 (13): 8737–45. doi:10.1074/jbc.274.13.8737. PMID 10085114.
• Rebhun JF, Castro AF, Quilliam LA (2001). "Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction". J. Biol. Chem. 275 (45): 34901–8. doi:10.1074/jbc.M005327200. PMID 10934204.
• Nancy V, Callebaut I, El Marjou A, de Gunzburg J (2002). "The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases". J. Biol. Chem. 277 (17): 15076–84. doi:10.1074/jbc.M109983200. PMID 11786539.
• Evellin S, Nolte J, Tysack K, et al. (2002). "Stimulation of phospholipase C-epsilon by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B". J. Biol. Chem. 277 (19): 16805–13. doi:10.1074/jbc.M112024200. PMID 11877431.
• Song C, Satoh T, Edamatsu H, et al. (2002). "Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon". Oncogene 21 (53): 8105–13. doi:10.1038/sj.onc.1206003. PMID 12444546.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Greco F, Sinigaglia F, Balduini C, Torti M (2005). "Activation of the small GTPase Rap2B in agonist-stimulated human platelets". J. Thromb. Haemost. 2 (12): 2223–30. doi:10.1111/j.1538-7836.2004.01018.x. PMID 15613030.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Liu Y, Sun W, Zhang K, et al. (2007). "Identification of genes differentially expressed in human primary lung squamous cell carcinoma". Lung Cancer 56 (3): 307–17. doi:10.1016/j.lungcan.2007.01.016. PMID 17316888.