RAPGEF6

Rap guanine nucleotide exchange factor (GEF) 6
PDB rendering based on 2d93.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2D93​, 3LNY​
Identifiers
Symbols	RAPGEF6 ; KIA001LB; PDZ-GEF2; PDZGEF2; RA-GEF-2; RAGEF2
External IDs	OMIM: 610499 MGI: 2384761 HomoloGene: 22968 GeneCards: RAPGEF6 Gene
Gene ontology Molecular function • guanyl-nucleotide exchange factor activity • protein binding • Ras GTPase binding • GTP-dependent protein binding • phosphatidic acid binding Cellular component • cytosol • plasma membrane • apical plasma membrane • endocytic vesicle Biological process • Ras protein signal transduction • microvillus assembly • regulation of GTPase activity • positive regulation of GTPase activity • protein localization to plasma membrane • establishment of endothelial intestinal barrier Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51735	192786
Ensembl	ENSG00000158987	ENSMUSG00000037533
UniProt	Q8TEU7	Q5DTR1
RefSeq (mRNA)	NM_001164386	NM_001252494
RefSeq (protein)	NP_001157858	NP_001239423
Location (UCSC)	Chr 5: 131.42 – 131.64 Mb	Chr 11: 54.52 – 54.7 Mb
PubMed search

Rap guanine nucleotide exchange factor 6 is a protein that in humans is encoded by the RAPGEF6 gene.^[1][2][3]

References

1. Gao X, Satoh T, Liao Y, Song C, Hu CD, Kariya Ki K, Kataoka T (Nov 2001). "Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a downstream target of M-Ras". J Biol Chem 276 (45): 42219–42225. doi:10.1074/jbc.M105760200. PMID 11524421.
2. Kozlov G, Banville D, Gehring K, Ekiel I (Jul 2002). "Solution structure of the PDZ2 domain from cytosolic human phosphatase hPTP1E complexed with a peptide reveals contribution of the beta2-beta3 loop to PDZ domain-ligand interactions". J Mol Biol 320 (4): 813–820. doi:10.1016/S0022-2836(02)00544-2. PMID 12095257.
3. "Entrez Gene: RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6".

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Chen X, Wang X, Hossain S, et al. (2006). "Haplotypes spanning SPEC2, PDZ-GEF2 and ACSL6 genes are associated with schizophrenia". Hum. Mol. Genet. 15 (22): 3329–3342. doi:10.1093/hmg/ddl409. PMID 17030554.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–12135. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Kuiperij HB, de Rooij J, Rehmann H, et al. (2003). "Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2". Biochim. Biophys. Acta 1593 (2–3): 141–149. doi:10.1016/S0167-4889(02)00365-8. PMID 12581858.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.