RAPH1

Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4GMV​, 4GN1​
Identifiers
Symbols	RAPH1 ; ALS2CR18; ALS2CR9; LPD; PREL-2; PREL2; RMO1; RalGDS/AF-6
External IDs	OMIM: 609035 MGI: 1924550 HomoloGene: 71030 GeneCards: RAPH1 Gene
Gene ontology Molecular function • protein binding Cellular component • cytoplasm • cytoskeleton • plasma membrane • lamellipodium • filopodium Biological process • cell-matrix adhesion • signal transduction • axon extension Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	65059	77300
Ensembl	ENSG00000173166	ENSMUSG00000026014
UniProt	Q70E73	F2Z3U3
RefSeq (mRNA)	NM_025252	NM_001045513
RefSeq (protein)	NP_976241	NP_001038978
Location (UCSC)	Chr 2: 203.39 – 203.54 Mb	Chr 1: 60.48 – 60.57 Mb
PubMed search

Ras-associated and pleckstrin homology domains-containing protein 1 is a protein that in humans is encoded by the RAPH1 gene.^[1]

References

1. "Entrez Gene: RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1".

Further reading

• Nagase T, Kikuno R, Hattori A, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
• Hadano S, Hand CK, Osuga H, et al. (2001). "A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2.". Nat. Genet. 29 (2): 166–73. doi:10.1038/ng1001-166. PMID 11586298.
• Salazar MA, Kwiatkowski AV, Pellegrini L, et al. (2004). "Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton.". J. Biol. Chem. 278 (49): 49031–43. doi:10.1074/jbc.M308104200. PMID 14506234.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Krause M, Leslie JD, Stewart M, et al. (2004). "Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics.". Dev. Cell 7 (4): 571–83. doi:10.1016/j.devcel.2004.07.024. PMID 15469845.
• Dahl E, Sadr-Nabavi A, Klopocki E, et al. (2005). "Systematic identification and molecular characterization of genes differentially expressed in breast and ovarian cancer.". J. Pathol. 205 (1): 21–8. doi:10.1002/path.1687. PMID 15586368.
• Eppert K, Wunder JS, Aneliunas V, et al. (2005). "Altered expression and deletion of RMO1 in osteosarcoma.". Int. J. Cancer 114 (5): 738–46. doi:10.1002/ijc.20786. PMID 15609301.
• Jenzora A, Behrendt B, Small JV, et al. (2005). "PREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/VASP proteins.". FEBS Lett. 579 (2): 455–63. doi:10.1016/j.febslet.2004.10.110. PMID 15642358.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.