RASD1

RAS, dexamethasone-induced 1
Identifiers
Symbols	RASD1 ; AGS1; DEXRAS1; MGC:26290
External IDs	OMIM: 605550 MGI: 1270848 HomoloGene: 7509 GeneCards: RASD1 Gene
Gene ontology Molecular function • GTPase activity • protein binding • GTP binding Cellular component • nucleus • plasma membrane • sarcoplasmic reticulum • perinuclear region of cytoplasm Biological process • signal transduction • G-protein coupled receptor signaling pathway • nitric oxide mediated signal transduction • small GTPase mediated signal transduction • negative regulation of transcription, DNA-templated Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51655	19416
Ensembl	ENSG00000108551	ENSMUSG00000049892
UniProt	Q9Y272	O35626
RefSeq (mRNA)	NM_001199989	NM_009026
RefSeq (protein)	NP_001186918	NP_033052
Location (UCSC)	Chr 17: 17.49 – 17.5 Mb	Chr 11: 59.96 – 59.96 Mb
PubMed search

Dexamethasone-induced Ras-related protein 1 is a protein that in humans is encoded by the RASD1 gene.^[1][2]

Function

This gene encodes a Ras-related protein that is stimulated by dexamethasone. The exact function of this gene is unknown, but it may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. In addition, studies of a similar rat protein suggest that it functions as a novel physiologic nitric oxide (NO) effector. The gene product belongs to the Ras superfamily of small GTPases.^[2]

Interactions

RASD1 has been shown to interact with NOS1AP.^[3]

References

1. St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, Kinzler KW (Aug 2000). "Genes expressed in human tumor endothelium". Science 289 (5482): 1197–202. doi:10.1126/science.289.5482.1197. PMID 10947988.
2. "Entrez Gene: RASD1 RAS, dexamethasone-induced 1".
3. Fang M, Jaffrey SR, Sawa A, Ye K, Luo X, Snyder SH (Oct 2000). "Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON". Neuron 28 (1): 183–93. doi:10.1016/S0896-6273(00)00095-7. PMID 11086993.

Further reading

• Kemppainen RJ, Behrend EN (Feb 1998). "Dexamethasone rapidly induces a novel ras superfamily member-related gene in AtT-20 cells". The Journal of Biological Chemistry 273 (6): 3129–31. doi:10.1074/jbc.273.6.3129. PMID 9452419.
• Cismowski MJ, Takesono A, Ma C, Lizano JS, Xie X, Fuernkranz H, Lanier SM, Duzic E (Sep 1999). "Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling". Nature Biotechnology 17 (9): 878–83. doi:10.1038/12867. PMID 10471929.
• Tu Y, Wu C (Dec 1999). "Cloning, expression and characterization of a novel human Ras-related protein that is regulated by glucocorticoid hormone". Biochimica et Biophysica Acta 1489 (2-3): 452–6. doi:10.1016/s0167-4781(99)00197-9. PMID 10673050.
• Cismowski MJ, Ma C, Ribas C, Xie X, Spruyt M, Lizano JS, Lanier SM, Duzic E (Aug 2000). "Activation of heterotrimeric G-protein signaling by a ras-related protein. Implications for signal integration". The Journal of Biological Chemistry 275 (31): 23421–4. doi:10.1074/jbc.C000322200. PMID 10840027.
• Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Fang M, Jaffrey SR, Sawa A, Ye K, Luo X, Snyder SH (Oct 2000). "Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON". Neuron 28 (1): 183–93. doi:10.1016/S0896-6273(00)00095-7. PMID 11086993.
• Ognjanovic S, Bao S, Yamamoto SY, Garibay-Tupas J, Samal B, Bryant-Greenwood GD (Apr 2001). "Genomic organization of the gene coding for human pre-B-cell colony enhancing factor and expression in human fetal membranes". Journal of Molecular Endocrinology 26 (2): 107–17. doi:10.1677/jme.0.0260107. PMID 11241162.
• Takesono A, Nowak MW, Cismowski M, Duzic E, Lanier SM (Apr 2002). "Activator of G-protein signaling 1 blocks GIRK channel activation by a G-protein-coupled receptor: apparent disruption of receptor signaling complexes". The Journal of Biological Chemistry 277 (16): 13827–30. doi:10.1074/jbc.M201064200. PMID 11842095.
• Bi W, Yan J, Stankiewicz P, Park SS, Walz K, Boerkoel CF, Potocki L, Shaffer LG, Devriendt K, Nowaczyk MJ, Inoue K, Lupski JR (May 2002). "Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse". Genome Research 12 (5): 713–28. doi:10.1101/gr.73702. PMC 186594. PMID 11997338.
• Jaffrey SR, Fang M, Snyder SH (Dec 2002). "Nitrosopeptide mapping: a novel methodology reveals s-nitrosylation of dexras1 on a single cysteine residue". Chemistry & Biology 9 (12): 1329–35. doi:10.1016/S1074-5521(02)00293-4. PMID 12498886.
• Kemppainen RJ, Cox E, Behrend EN, Brogan MD, Ammons JM (Jun 2003). "Identification of a glucocorticoid response element in the 3'-flanking region of the human Dexras1 gene". Biochimica Et Biophysica Acta 1627 (2-3): 85–9. doi:10.1016/s0167-4781(03)00079-4. PMID 12818426.
• Vaidyanathan G, Cismowski MJ, Wang G, Vincent TS, Brown KD, Lanier SM (Jul 2004). "The Ras-related protein AGS1/RASD1 suppresses cell growth". Oncogene 23 (34): 5858–63. doi:10.1038/sj.onc.1207774. PMID 15184869.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Hiskens R, Vatish M, Hill C, Davey J, Ladds G (Dec 2005). "Specific in vivo binding of activator of G protein signalling 1 to the Gbeta1 subunit". Biochemical and Biophysical Research Communications 337 (4): 1038–46. doi:10.1016/j.bbrc.2005.09.149. PMID 16225846.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Nguyen CH, Watts VJ (May 2006). "Dexamethasone-induced Ras protein 1 negatively regulates protein kinase C delta: implications for adenylyl cyclase 2 signaling". Molecular Pharmacology 69 (5): 1763–71. doi:10.1124/mol.105.019133. PMID 16489124.
• Compton SL, Kemppainen RJ, Behrend EN (Dec 2009). "Prenylated Rab acceptor domain family member 1 is involved in stimulated ACTH secretion and inhibition". Cellular Signalling 21 (12): 1901–9. doi:10.1016/j.cellsig.2009.08.007. PMID 19733236.