RASGEF1A

RasGEF domain family, member 1A
Identifiers
Symbols	RASGEF1A ; CG4853
External IDs	OMIM: 614531 HomoloGene: 17067 GeneCards: RASGEF1A Gene
Gene ontology Molecular function • Ras guanyl-nucleotide exchange factor activity Cellular component • intracellular Biological process • small GTPase mediated signal transduction • cell migration • positive regulation of GTPase activity • positive regulation of GTPase activity • positive regulation of Ras protein signal transduction Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	221002	70727
Ensembl	ENSG00000198915	ENSMUSG00000030134
UniProt	Q8N9B8	n/a
RefSeq (mRNA)	NM_001282862	NM_027526
RefSeq (protein)	NP_001269791	NP_081802
Location (UCSC)	Chr 10: 43.19 – 43.27 Mb	Chr 6: 118.07 – 118.09 Mb
PubMed search

RasGEF domain family, member 1A is a protein that in humans is encoded by the RASGEF1A gene.^[1]

References

1. "Entrez Gene: RasGEF domain family, member 1A".

Further reading

• Ura K, Obama K, Satoh S, Sakai Y, Nakamura Y, Furukawa Y (Nov 2006). "Enhanced RASGEF1A expression is involved in the growth and migration of intrahepatic cholangiocarcinoma". Clinical Cancer Research 12 (22): 6611–6. doi:10.1158/1078-0432.CCR-06-0783. PMID 17121879.
• Emison ES, McCallion AS, Kashuk CS, Bush RT, Grice E, Lin S, Portnoy ME, Cutler DJ, Green ED, Chakravarti A (Apr 2005). "A common sex-dependent mutation in a RET enhancer underlies Hirschsprung disease risk". Nature 434 (7035): 857–63. doi:10.1038/nature03467. PMID 15829955.
• Garcia-Barcelo MM, Tang CS, Ngan ES, Lui VC, Chen Y, So MT, Leon TY, Miao XP, Shum CK, Liu FQ, Yeung MY, Yuan ZW, Guo WH, Liu L, Sun XB, Huang LM, Tou JF, Song YQ, Chan D, Cheung KM, Wong KK, Cherny SS, Sham PC, Tam PK (Feb 2009). "Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease". Proceedings of the National Academy of Sciences of the United States of America 106 (8): 2694–9. doi:10.1073/pnas.0809630105. PMID 19196962.
• Yaman E, Gasper R, Koerner C, Wittinghofer A, Tazebay UH (Aug 2009). "RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2-specific nucleotide exchange". The FEBS Journal 276 (16): 4607–16. doi:10.1111/j.1742-4658.2009.07166.x. PMID 19645719.
• Burzynski GM, Nolte IM, Bronda A, Bos KK, Osinga J, Plaza Menacho I, Twigt B, Maas S, Brooks AS, Verheij JB, Buys CH, Hofstra RM (May 2005). "Identifying candidate Hirschsprung disease-associated RET variants". American Journal of Human Genetics 76 (5): 850–8. doi:10.1086/429589. PMID 15759212.