RASGRF1

Ras protein-specific guanine nucleotide-releasing factor 1
Identifiers
Symbols	RASGRF1 ; CDC25; CDC25L; GNRP; GRF1; GRF55; H-GRF55; PP13187; ras-GRF1
External IDs	OMIM: 606600 HomoloGene: 74972 GeneCards: RASGRF1 Gene
Gene ontology Molecular function • guanyl-nucleotide exchange factor activity • Ras guanyl-nucleotide exchange factor activity • Rho guanyl-nucleotide exchange factor activity • glutamate receptor binding Cellular component • cytosol • plasma membrane • growth cone • neuron projection Biological process • signal transduction • small GTPase mediated signal transduction • synaptic transmission • long-term memory • cell proliferation • neuron projection development • regulation of Rac protein signal transduction • regulation of Rho protein signal transduction • positive regulation of GTPase activity • regulation of Ras protein signal transduction • positive regulation of Ras protein signal transduction • regulation of synaptic plasticity • regulation of neuronal synaptic plasticity • activation of GTPase activity • regulation of N-methyl-D-aspartate selective glutamate receptor activity Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5923	19417
Ensembl	ENSG00000058335	ENSMUSG00000032356
UniProt	Q13972	P27671
RefSeq (mRNA)	NM_001145648	NM_001039655
RefSeq (protein)	NP_001139120	NP_001034744
Location (UCSC)	Chr 15: 78.96 – 79.09 Mb	Chr 9: 89.91 – 90.03 Mb
PubMed search

Ras protein-specific guanine nucleotide-releasing factor 1 is a protein in humans that is encoded by the RASGRF1 gene. ^[1]

The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein.

The studies of the similar gene in mice suggested that the Ras-GEF activity of this protein in the brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009].

References

1. "Entrez Gene: Ras protein-specific guanine nucleotide-releasing factor 1". Retrieved 2013-04-07.

Further reading