RBBP5

Retinoblastoma binding protein 5
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols RBBP5 ; RBQ3; SWD1
External IDs OMIM: 600697 MGI: 1918367 HomoloGene: 3709 GeneCards: RBBP5 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 5929 213464
Ensembl ENSG00000117222 ENSMUSG00000026439
UniProt Q15291 Q8BX09
RefSeq (mRNA) NM_001193272 NM_172517
RefSeq (protein) NP_001180201 NP_766105
Location (UCSC) Chr 1:
205.09 – 205.12 Mb
Chr 1:
132.48 – 132.51 Mb
PubMed search

Retinoblastoma-binding protein 5 is a protein that in humans is encoded by the RBBP5 gene.[1][2]

Function

The protein encoded by this gene is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B.[2]

Interactions

RBBP5 has been shown to interact with:

References

  1. Saijo M, Sakai Y, Kishino T, Niikawa N, Matsuura Y, Morino K, Tamai K, Taya Y (Jun 1995). "Molecular cloning of a human protein that binds to the retinoblastoma protein and chromosomal mapping". Genomics 27 (3): 511–9. doi:10.1006/geno.1995.1084. PMID 7558034.
  2. 1 2 "Entrez Gene: RBBP5 retinoblastoma binding protein 5".
  3. 1 2 3 Goo YH, Sohn YC, Kim DH, Kim SW, Kang MJ, Jung DJ, Kwak E, Barlev NA, Berger SL, Chow VT, Roeder RG, Azorsa DO, Meltzer PS, Suh PG, Song EJ, Lee KJ, Lee YC, Lee JW (Jan 2003). "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins". Molecular and Cellular Biology 23 (1): 140–9. PMC 140670. PMID 12482968.
  4. Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero DJ, Kitabayashi I, Herr W, Cleary ML (Jul 2004). "Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression". Molecular and Cellular Biology 24 (13): 5639–49. doi:10.1128/MCB.24.13.5639-5649.2004. PMC 480881. PMID 15199122.

Further reading

This article is issued from Wikipedia - version of the Sunday, November 29, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.