RBBP9

Retinoblastoma binding protein 9
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2QS9​
Identifiers
Symbols	RBBP9 ; BOG; RBBP10
External IDs	OMIM: 602908 MGI: 1347074 HomoloGene: 4816 ChEMBL: 1075121 GeneCards: RBBP9 Gene
Gene ontology Molecular function • hydrolase activity Cellular component • nucleus • nucleoplasm • nucleolus • cytoplasm • extracellular exosome Biological process • metabolic process • regulation of cell proliferation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10741	26450
Ensembl	ENSG00000089050	ENSMUSG00000027428
UniProt	O75884	O88851
RefSeq (mRNA)	NM_006606	NM_015754
RefSeq (protein)	NP_006597	NP_056569
Location (UCSC)	Chr 20: 18.49 – 18.5 Mb	Chr 2: 144.54 – 144.55 Mb
PubMed search

Putative hydrolase RBBP9 is an enzyme that in humans is encoded by the RBBP9 gene.^[1][2][3]

Function

The protein encoded by this gene is a retinoblastoma binding protein that may play a role in the regulation of cell proliferation and differentiation. Two alternatively spliced transcript variants of this gene with identical predicted protein products have been reported, one of which is a nonsense-mediated decay candidate.^[3]

Interactions

RBBP9 has been shown to interact with Retinoblastoma protein.^[1]

References

1. Woitach JT, Zhang M, Niu CH, Thorgeirsson SS (Aug 1998). "A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability". Nature Genetics 19 (4): 371–4. doi:10.1038/1258. PMID 9697699.
2. Woitach JT, Hong R, Keck CL, Zimonjic DB, Popescu NC, Thorgeirsson SS (Oct 1999). "Assignment of the Bog gene (RBBP9) to syntenic regions of mouse chromosome 2G1-H1 and human chromosome 20p11.2 by fluorescence in situ hybridization". Cytogenetics and Cell Genetics 85 (3-4): 252–3. doi:10.1159/000015304. PMID 10449909.
3. "Entrez Gene: RBBP9 retinoblastoma binding protein 9".

Further reading

• Chen JZ, Yang QS, Wang S, Meng XF, Ying K, Xie Y, Ma YM (Aug 2002). "Cloning and expression of a novel retinoblastoma binding protein cDNA, RBBP10". Biochemical Genetics 40 (7-8): 273–82. doi:10.1023/A:1019886918029. PMID 12296629.
• Chen J, Ji C, Gu S, Zhao E, Dai J, Huang L, Qian J, Ying K, Xie Y, Mao Y (2003). "Isolation and identification of a novel cDNA that encodes human yrdC protein". Journal of Human Genetics 48 (4): 164–9. doi:10.1007/s10038-002-0001-3. PMID 12730717.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.