RBM15

RNA binding motif protein 15
Identifiers
Symbols	RBM15 ; OTT; OTT1; SPEN
External IDs	OMIM: 606077 MGI: 2443205 HomoloGene: 23383 GeneCards: RBM15 Gene
Gene ontology Molecular function • nucleotide binding • protein binding • poly(A) RNA binding Cellular component • nucleoplasm • nuclear membrane Biological process • patterning of blood vessels • positive regulation of transcription of Notch receptor target • viral process • negative regulation of myeloid cell differentiation • negative regulation of transcription, DNA-templated • spleen development • ventricular septum morphogenesis • placenta blood vessel development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	64783	229700
Ensembl	ENSG00000162775	ENSMUSG00000048109
UniProt	Q96T37	A0PJG5
RefSeq (mRNA)	NM_001201545	NM_001045807
RefSeq (protein)	NP_001188474	NP_001039272
Location (UCSC)	Chr 1: 110.34 – 110.35 Mb	Chr 3: 107.33 – 107.33 Mb
PubMed search

Putative RNA-binding protein 15 is a protein that in humans is encoded by the RBM15 gene.^[1][2][3]

References

1. Ma Z, Morris SW, Valentine V, Li M, Herbrick JA, Cui X, Bouman D, Li Y, Mehta PK, Nizetic D, Kaneko Y, Chan GC, Chan LC, Squire J, Scherer SW, Hitzler JK (Jun 2001). "Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia". Nat Genet 28 (3): 220–1. doi:10.1038/90054. PMID 11431691.
2. Mercher T, Coniat MB, Monni R, Mauchauffe M, Nguyen Khac F, Gressin L, Mugneret F, Leblanc T, Dastugue N, Berger R, Bernard OA (May 2001). "Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia". Proc Natl Acad Sci U S A 98 (10): 5776–9. doi:10.1073/pnas.101001498. PMC 33289. PMID 11344311.
3. "Entrez Gene: RBM15 RNA binding motif protein 15".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hsiao HH, Yang MY, Liu YC, et al. (2005). "RBM15-MKL1 (OTT-MAL) fusion transcript in an adult acute myeloid leukemia patient.". Am. J. Hematol. 79 (1): 43–5. doi:10.1002/ajh.20298. PMID 15849773.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Lindtner S, Zolotukhin AS, Uranishi H, et al. (2007). "RNA-binding motif protein 15 binds to the RNA transport element RTE and provides a direct link to the NXF1 export pathway.". J. Biol. Chem. 281 (48): 36915–28. doi:10.1074/jbc.M608745200. PMID 17001072.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.