RBM22

RNA binding motif protein 22
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2YTC​
Identifiers
Symbols	RBM22 ; Cwc2; ZC3H16; fSAP47
External IDs	OMIM: 612430 MGI: 1914060 HomoloGene: 69245 GeneCards: RBM22 Gene
Gene ontology Molecular function • nucleotide binding • nucleocytoplasmic transporter activity • protein binding • U6 snRNA binding • pre-mRNA binding • poly(A) RNA binding • metal ion binding • calcium-dependent protein binding Cellular component • Prp19 complex • nucleus • nucleoplasm • cytoplasm • U2-type catalytic step 1 spliceosome • U2-type catalytic step 2 spliceosome • catalytic step 2 spliceosome Biological process • protein import into nucleus, translocation • spliceosomal snRNP assembly • mRNA splicing, via spliceosome • positive regulation of RNA splicing • cellular response to drug • mRNA cis splicing, via spliceosome • positive regulation of intracellular protein transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55696	66810
Ensembl	ENSG00000086589	ENSMUSG00000024604
UniProt	Q9NW64	Q8BHS3
RefSeq (mRNA)	NM_018047	NM_025776
RefSeq (protein)	NP_060517	NP_080052
Location (UCSC)	Chr 5: 150.69 – 150.7 Mb	Chr 18: 60.56 – 60.57 Mb
PubMed search

Pre-mRNA-splicing factor RBM22 is a protein that in humans is encoded by the RBM22 gene.^[1][2]

References

1. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
2. "Entrez Gene: RBM22 RNA binding motif protein 22".

Further reading

• Loftus SK, Dixon J, Koprivnikar K, et al. (1996). "Transcriptional map of the Treacher Collins candidate gene region". Genome Res. 6 (1): 26–34. doi:10.1101/gr.6.1.26. PMID 8681136.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Montaville P, Dai Y, Cheung CY, et al. (2007). "Nuclear translocation of the calcium-binding protein ALG-2 induced by the RNA-binding protein RBM22". Biochim. Biophys. Acta 1763 (11): 1335–43. doi:10.1016/j.bbamcr.2006.09.003. PMID 17045351.