RBM4

RNA binding motif protein 4
PDB rendering based on 2dgt.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2DNQ​
Identifiers
Symbols	RBM4 ; LARK; RBM4A; ZCCHC21; ZCRB3A
External IDs	OMIM: 602571 MGI: 1100865 HomoloGene: 82510 GeneCards: RBM4 Gene
Gene ontology Molecular function • nucleotide binding • RNA binding • mRNA binding • mRNA 3'-UTR binding • protein binding • zinc ion binding • miRNA binding • poly(A) RNA binding • pre-mRNA intronic binding • pre-mRNA intronic pyrimidine-rich binding Cellular component • nucleus • nucleoplasm • nucleolus • cytoplasm • cytoplasmic stress granule • nuclear speck Biological process • regulation of alternative mRNA splicing, via spliceosome • cap-independent translational initiation • IRES-dependent translational initiation • RNA processing • mRNA processing • RNA splicing • negative regulation of translation • cell differentiation • negative regulation of translation in response to stress • negative regulation of translation involved in gene silencing by miRNA • entrainment of circadian clock by photoperiod • negative regulation of translational initiation • response to arsenic-containing substance • regulation of nucleocytoplasmic transport • positive regulation of muscle cell differentiation • stress-activated MAPK cascade • circadian regulation of translation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5936	19653
Ensembl	ENSG00000173933	ENSMUSG00000094936
UniProt	Q9BWF3	Q8C7Q4
RefSeq (mRNA)	NM_001198843	NM_001290122
RefSeq (protein)	NP_001185772	NP_001277051
Location (UCSC)	Chr 11: 66.64 – 66.67 Mb	Chr 19: 4.78 – 4.79 Mb
PubMed search

RNA-binding protein 4 is a protein that in humans is encoded by the RBM4 gene.^[1][2][3]

References

1. Jackson FR, Banfi S, Guffanti A, Rossi E (Jul 1997). "A novel zinc finger-containing RNA-binding protein conserved from fruitflies to humans". Genomics 41 (3): 444–52. doi:10.1006/geno.1997.4704. PMID 9169144.
2. Lin JC, Tarn WY (Nov 2005). "Exon selection in alpha-tropomyosin mRNA is regulated by the antagonistic action of RBM4 and PTB". Mol Cell Biol 25 (22): 10111–21. doi:10.1128/MCB.25.22.10111-10121.2005. PMC 1280272. PMID 16260624.
3. "Entrez Gene: RBM4 RNA binding motif protein 4".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
• Bernert G, Fountoulakis M, Lubec G (2003). "Manifold decreased protein levels of matrin 3, reduced motor protein HMP and hlark in fetal Down's syndrome brain.". Proteomics 2 (12): 1752–7. doi:10.1002/1615-9861(200212)2:12<1752::AID-PROT1752>3.0.CO;2-Y. PMID 12469345.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Petersen HH, Hilpert J, Militz D, et al. (2003). "Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule.". J. Cell. Sci. 116 (Pt 3): 453–61. doi:10.1242/jcs.00243. PMID 12508107.
• Lai MC, Kuo HW, Chang WC, Tarn WY (2003). "A novel splicing regulator shares a nuclear import pathway with SR proteins.". EMBO J. 22 (6): 1359–69. doi:10.1093/emboj/cdg126. PMC 151058. PMID 12628928.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Diederichs S, Bäumer N, Ji P, et al. (2004). "Identification of interaction partners and substrates of the cyclin A1-CDK2 complex.". J. Biol. Chem. 279 (32): 33727–41. doi:10.1074/jbc.M401708200. PMID 15159402.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Kar A, Havlioglu N, Tarn WY, Wu JY (2006). "RBM4 interacts with an intronic element and stimulates tau exon 10 inclusion.". J. Biol. Chem. 281 (34): 24479–88. doi:10.1074/jbc.M603971200. PMC 2072872. PMID 16777844.
• Markus MA, Heinrich B, Raitskin O, et al. (2006). "WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo.". Exp. Cell Res. 312 (17): 3379–88. doi:10.1016/j.yexcr.2006.07.008. PMID 16934801.
• Lin JC, Hsu M, Tarn WY (2007). "Cell stress modulates the function of splicing regulatory protein RBM4 in translation control.". Proc. Natl. Acad. Sci. U.S.A. 104 (7): 2235–40. doi:10.1073/pnas.0611015104. PMC 1893002. PMID 17284590.