RCHY1

Ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase

Rendering based on PDB 2JRJ.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols RCHY1 ; ARNIP; CHIMP; PIRH2; PRO1996; RNF199; ZCHY; ZNF363
External IDs OMIM: 607680 MGI: 1915348 HomoloGene: 22894 GeneCards: RCHY1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 25898 68098
Ensembl ENSG00000163743 ENSMUSG00000029397
UniProt Q96PM5 Q9CR50
RefSeq (mRNA) NM_001008925 NM_001271797
RefSeq (protein) NP_001009922 NP_001258726
Location (UCSC) Chr 4:
75.48 – 75.51 Mb
Chr 5:
91.95 – 91.96 Mb
PubMed search

RING finger and CHY zinc finger domain-containing protein 1 is a protein that in humans is encoded by the RCHY1 gene.[1]

Function

The protein encoded by this gene has ubiquitin-protein ligase activity. This protein binds with p53 and promotes the ubiquitin-mediated proteosomal degradation of p53. This gene is oncogenic because loss of p53 function contributes directly to malignant tumor development. Transcription of this gene is regulated by p53. Alternative splicing results in multiple transcript variants encoding different isoforms.[1]

Interactions

RCHY1 has been shown to interact with P53[2][3] and Androgen receptor.[4]

References

  1. 1 2 "Entrez Gene: RCHY1 ring finger and CHY zinc finger domain containing 1".
  2. Leng RP, Lin Y, Ma W, Wu H, Lemmers B, Chung S, Parant JM, Lozano G, Hakem R, Benchimol S (Mar 2003). "Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation". Cell 112 (6): 779–91. doi:10.1016/S0092-8674(03)00193-4. PMID 12654245.
  3. Sheng Y, Laister RC, Lemak A, Wu B, Tai E, Duan S, Lukin J, Sunnerhagen M, Srisailam S, Karra M, Benchimol S, Arrowsmith CH (Dec 2008). "Molecular basis of Pirh2-mediated p53 ubiquitylation". Nature Structural & Molecular Biology 15 (12): 1334–42. doi:10.1038/nsmb.1521. PMID 19043414.
  4. Beitel LK, Elhaji YA, Lumbroso R, Wing SS, Panet-Raymond V, Gottlieb B, Pinsky L, Trifiro MA (Aug 2002). "Cloning and characterization of an androgen receptor N-terminal-interacting protein with ubiquitin-protein ligase activity". Journal of Molecular Endocrinology 29 (1): 41–60. doi:10.1677/jme.0.0290041. PMID 12200228.

Further reading

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