RECQL5

RecQ helicase-like 5
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4BK0​
Identifiers
Symbols	RECQL5 ; RECQ5
External IDs	OMIM: 603781 MGI: 2156841 HomoloGene: 31232 GeneCards: RECQL5 Gene
EC number	3.6.4.12
Gene ontology Molecular function • RNA polymerase II core binding • nucleic acid binding • DNA helicase activity • ATP binding • ATP-dependent helicase activity Cellular component • nucleus • nucleoplasm • nucleolus • cytoplasm • DNA-directed RNA polymerase II, holoenzyme • nuclear membrane Biological process • DNA metabolic process • DNA replication • DNA repair • DNA recombination • mitotic nuclear division • DNA duplex unwinding • negative regulation of transcription elongation from RNA polymerase II promoter • cell division • chromosome separation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9400	170472
Ensembl	ENSG00000108469	ENSMUSG00000020752
UniProt	O94762	Q8VID5
RefSeq (mRNA)	NM_001003715	NM_130454
RefSeq (protein)	NP_001003715	NP_569721
Location (UCSC)	Chr 17: 75.63 – 75.67 Mb	Chr 11: 115.89 – 115.93 Mb
PubMed search

ATP-dependent DNA helicase Q5 is an enzyme that in humans is encoded by the RECQL5 gene.^[1][2]

Interactions

RECQL5 has been shown to interact with EEF1G.^[3]

References

1. Kitao S, Ohsugi I, Ichikawa K, Goto M, Furuichi Y, Shimamoto A (Dec 1998). "Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes". Genomics 54 (3): 443–52. doi:10.1006/geno.1998.5595. PMID 9878247.
2. "Entrez Gene: RECQL5 RecQ protein-like 5".
3. Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.

Further reading

• Sekelsky JJ, Brodsky MH, Rubin GM, Hawley RS (Sep 1999). "Drosophila and human RecQ5 exist in different isoforms generated by alternative splicing". Nucleic Acids Research 27 (18): 3762–9. doi:10.1093/nar/27.18.3762. PMC 148633. PMID 10471747.
• Shimamoto A, Nishikawa K, Kitao S, Furuichi Y (Apr 2000). "Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta". Nucleic Acids Research 28 (7): 1647–55. doi:10.1093/nar/28.7.1647. PMC 102787. PMID 10710432.
• Garcia PL, Liu Y, Jiricny J, West SC, Janscak P (Jul 2004). "Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide". The EMBO Journal 23 (14): 2882–91. doi:10.1038/sj.emboj.7600301. PMC 514958. PMID 15241474.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
• Hu Y, Lu X, Barnes E, Yan M, Lou H, Luo G (May 2005). "Recql5 and Blm RecQ DNA helicases have nonredundant roles in suppressing crossovers". Molecular and Cellular Biology 25 (9): 3431–42. doi:10.1128/MCB.25.9.3431-3442.2005. PMC 1084310. PMID 15831450.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Kanagaraj R, Saydam N, Garcia PL, Zheng L, Janscak P (2006). "Human RECQ5beta helicase promotes strand exchange on synthetic DNA structures resembling a stalled replication fork". Nucleic Acids Research 34 (18): 5217–31. doi:10.1093/nar/gkl677. PMC 1635296. PMID 17003056.
• Hu Y, Raynard S, Sehorn MG, Lu X, Bussen W, Zheng L, Stark JM, Barnes EL, Chi P, Janscak P, Jasin M, Vogel H, Sung P, Luo G (Dec 2007). "RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments". Genes & Development 21 (23): 3073–84. doi:10.1101/gad.1609107. PMC 2081974. PMID 18003859.