RENBP

Renin binding protein
Identifiers
Symbols	RENBP ; RBP; RNBP
External IDs	OMIM: 312420 MGI: 105940 HomoloGene: 2184 GeneCards: RENBP Gene
EC number	5.1.3.8
Gene ontology Molecular function • endopeptidase inhibitor activity • ATP binding • protein homodimerization activity • N-acylglucosamine 2-epimerase activity Cellular component • extracellular exosome Biological process • N-acetylglucosamine metabolic process • N-acetylmannosamine metabolic process • regulation of blood pressure • negative regulation of endopeptidase activity • N-acetylneuraminate catabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5973	19703
Ensembl	ENSG00000102032	ENSMUSG00000031387
UniProt	P51606	P82343
RefSeq (mRNA)	NM_002910	NM_001164704
RefSeq (protein)	NP_002901	NP_001158176
Location (UCSC)	Chr X: 153.94 – 153.94 Mb	Chr X: 73.92 – 73.93 Mb
PubMed search

N-acylglucosamine 2-epimerase is an enzyme that in humans is encoded by the RENBP gene.^[1][2]

The gene product inhibits renin activity by forming a dimer with renin, a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature.^[2]

References

1. Takahashi S, Inoue H, Miyake Y (Aug 1992). "The human gene for renin-binding protein". J Biol Chem 267 (18): 13007–13. PMID 1618798.
2. "Entrez Gene: RENBP renin binding protein".

Further reading

• Inoue H, Takahashi S, Fukui K, Miyake Y (1992). "Genetic and molecular properties of human and rat renin-binding proteins with reference to the function of the leucine zipper motif". J. Biochem. 110 (4): 493–500. PMID 1723410.
• Takahashi S, Miura R, Miyake Y (1985). "A study on renin binding protein (RnBP) in the human kidney". J. Biochem. 97 (2): 671–7. PMID 3924907.
• Murakami K, Hirose S, Chino S, et al. (1983). "Properties of renin-binding protein". Clinical and experimental hypertension. Part A, Theory and practice 4 (11–12): 2073–81. doi:10.3109/10641968209062372. PMID 6756682.
• Faranda S, Frattini A, Vezzoni P (1995). "The human genes encoding renin-binding protein and host cell factor are closely linked in Xq28 and transcribed in the same direction". Gene 155 (2): 237–9. doi:10.1016/0378-1119(94)00810-F. PMID 7721097.
• van den Ouweland AM, Verdijk M, Kiochis P, et al. (1994). "The human renin-binding protein gene (RENBP) maps in Xq28". Genomics 21 (1): 279–81. doi:10.1006/geno.1994.1259. PMID 8088804.
• Knöll A, Schunkert H, Reichwald K, et al. (1998). "Human renin binding protein: complete genomic sequence and association of an intronic T/C polymorphism with the prorenin level in males". Hum. Mol. Genet. 6 (9): 1527–34. doi:10.1093/hmg/6.9.1527. PMID 9285790.
• Brenner V, Nyakatura G, Rosenthal A, Platzer M (1997). "Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse". Genomics 44 (1): 8–14. doi:10.1006/geno.1997.4822. PMID 9286695.
• Stäsche R, Hinderlich S, Weise C, et al. (1997). "A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Molecular cloning and functional expression of UDP-N-acetyl-glucosamine 2-epimerase/N-acetylmannosamine kinase". J. Biol. Chem. 272 (39): 24319–24. doi:10.1074/jbc.272.39.24319. PMID 9305888.
• Takahashi S, Takahashi K, Kaneko T, et al. (1999). "Human renin-binding protein is the enzyme N-acetyl-D-glucosamine 2-epimerase". J. Biochem. 125 (2): 348–53. doi:10.1093/oxfordjournals.jbchem.a022293. PMID 9990133.
• Takahashi S, Kumagai M, Shindo S, et al. (2001). "Renin inhibits N-acetyl-D-glucosamine 2-epimerase (renin-binding protein)". J. Biochem. 128 (6): 951–6. doi:10.1093/oxfordjournals.jbchem.a022846. PMID 11098137.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Lapteva N, Nieda M, Ando Y, et al. (2001). "Expression of renin-angiotensin system genes in immature and mature dendritic cells identified using human cDNA microarray". Biochem. Biophys. Res. Commun. 285 (4): 1059–65. doi:10.1006/bbrc.2001.5215. PMID 11467860.
• Takahashi S, Ogasawara H, Takahashi K, et al. (2002). "Identification of a domain conferring nucleotide binding to the N-acetyl-d-glucosamine 2-epimerase (Renin binding protein)". J. Biochem. 131 (4): 605–10. doi:10.1093/oxfordjournals.jbchem.a003140. PMID 11926999.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Luchansky SJ, Yarema KJ, Takahashi S, Bertozzi CR (2003). "GlcNAc 2-epimerase can serve a catabolic role in sialic acid metabolism". J. Biol. Chem. 278 (10): 8035–42. doi:10.1074/jbc.M212127200. PMID 12499362.
• Bohlmeyer T, Ferdensi A, Bristow MR, et al. (2003). "Selective activation of N-acyl-D-glucosamine 2-epimerase expression in failing human heart ventricular myocytes". J. Card. Fail. 9 (1): 59–68. doi:10.1054/jcaf.2003.6. PMID 12612874.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.