RGL2

Ral guanine nucleotide dissociation stimulator-like 2
PDB rendering based on 1rlf.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1rlf​
Identifiers
Symbols	RGL2 ; HKE1.5; KE1.5; RAB2L
External IDs	OMIM: 602306 MGI: 107483 HomoloGene: 3494 GeneCards: RGL2 Gene
Gene ontology Molecular function • Ras guanyl-nucleotide exchange factor activity • protein binding • Ral guanyl-nucleotide exchange factor activity Cellular component • cellular_component • intracellular Biological process • Ras protein signal transduction • positive regulation of GTPase activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5863	19732
Ensembl	ENSG00000206282	ENSMUSG00000041354
UniProt	O15211	Q61193
RefSeq (mRNA)	NM_001243738	NM_009059
RefSeq (protein)	NP_001230667	NP_033085
Location (UCSC)	Chr 6: 33.29 – 33.3 Mb	Chr 17: 33.93 – 33.94 Mb
PubMed search

Ral guanine nucleotide dissociation stimulator-like 2 is a protein that in humans is encoded by the RGL2 gene.^[1][2]

Interactions

RGL2 has been shown to interact with HRAS.^[3][4]

References

1. Isomura M, Okui K, Fujiwara T, Shin S, Nakamura Y (January 1997). "Isolation and mapping of RAB2L, a human cDNA that encodes a protein homologous to RalGDS". Cytogenet Cell Genet 74 (4): 263–5. doi:10.1159/000134431. PMID 8976381.
2. "Entrez Gene: RGL2 ral guanine nucleotide dissociation stimulator-like 2".
3. Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ (May 2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". J. Biol. Chem. 279 (21): 22353–61. doi:10.1074/jbc.M312867200. PMID 15031288.
4. Peterson SN, Trabalzini L, Brtva TR, Fischer T, Altschuler DL, Martelli P, Lapetina EG, Der CJ, White GC (November 1996). "Identification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1". J. Biol. Chem. 271 (47): 29903–8. doi:10.1074/jbc.271.47.29903. PMID 8939933.

Further reading

• Peterson SN, Trabalzini L, Brtva TR, Fischer T, Altschuler DL, Martelli P, Lapetina EG, Der CJ, White GC (1997). "Identification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1.". J. Biol. Chem. 271 (47): 29903–8. doi:10.1074/jbc.271.47.29903. PMID 8939933.
• Herberg JA, Sgouros J, Jones T, Copeman J, Humphray SJ, Sheer D, Cresswell P, Beck S, Trowsdale J (1998). "Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC.". Eur. J. Immunol. 28 (2): 459–67. doi:10.1002/(SICI)1521-4141(199802)28:02<459::AID-IMMU459>3.0.CO;2-Z. PMID 9521053.
• Herberg JA, Beck S, Trowsdale J (1998). "TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC.". J. Mol. Biol. 277 (4): 839–57. doi:10.1006/jmbi.1998.1637. PMID 9545376.
• Ando A, Kikuti YY, Abe K, Shigenari A, Kawata H, Ikemura T, Kimura M, Inoko H (1999). "cDNA cloning, northern hybridization, and mapping analysis of a putative GDS-related protein gene at the centromeric ends of the human and mouse MHC regions.". Immunogenetics 49 (4): 354–6. doi:10.1007/s002510050504. PMID 10079301.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ (2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization.". J. Biol. Chem. 279 (21): 22353–61. doi:10.1074/jbc.M312867200. PMID 15031288.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.