RGS11

Regulator of G-protein signaling 11
Identifiers
Symbols	RGS11 ; RS11
External IDs	OMIM: 603895 MGI: 1354739 HomoloGene: 77719 GeneCards: RGS11 Gene
Gene ontology Molecular function • signal transducer activity • GTPase activator activity • G-protein beta-subunit binding Cellular component • cytoplasm • heterotrimeric G-protein complex • plasma membrane • protein complex • dendrite terminus Biological process • G-protein coupled receptor signaling pathway • regulation of G-protein coupled receptor protein signaling pathway • intracellular signal transduction • termination of G-protein coupled receptor signaling pathway • positive regulation of GTPase activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8786	50782
Ensembl	ENSG00000076344	ENSMUSG00000024186
UniProt	O94810	G3X8W6
RefSeq (mRNA)	NM_001286485	NM_001081069
RefSeq (protein)	NP_001273414	NP_001074538
Location (UCSC)	Chr 16: 0.27 – 0.28 Mb	Chr 17: 26.2 – 26.21 Mb
PubMed search

Regulator of G-protein signaling 11 is a protein that in humans is encoded by the RGS11 gene.^[1][2]

The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.^[2]

References

1. Snow BE, Krumins AM, Brothers GM, Lee SF, Wall MA, Chung S, Mangion J, Arya S, Gilman AG, Siderovski DP (Nov 1998). "A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits". Proc Natl Acad Sci U S A 95 (22): 13307–12. doi:10.1073/pnas.95.22.13307. PMC 23793. PMID 9789084.
2. "Entrez Gene: RGS11 regulator of G-protein signalling 11".

Further reading

• Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16.". Nature 432 (7020): 988–94. doi:10.1038/nature03187. PMID 15616553.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Sierra DA, Gilbert DJ, Householder D, et al. (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human.". Genomics 79 (2): 177–85. doi:10.1006/geno.2002.6693. PMID 11829488.
• Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
• Snow BE, Betts L, Mangion J, et al. (1999). "Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11.". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6489–94. doi:10.1073/pnas.96.11.6489. PMC 26909. PMID 10339615.
• Gold SJ, Ni YG, Dohlman HG, Nestler EJ (1997). "Regulators of G-protein signaling (RGS) proteins: region-specific expression of nine subtypes in rat brain.". J. Neurosci. 17 (20): 8024–37. PMID 9315921.