RGS13

Regulator of G-protein signaling 13
Identifiers
Symbols	RGS13 ; MGC17173
External IDs	OMIM: 607190 MGI: 2180585 HomoloGene: 14774 GeneCards: RGS13 Gene
Gene ontology Molecular function • GTPase activator activity Cellular component • nucleus • cytoplasm • cytosol • plasma membrane Biological process • G-protein coupled receptor signaling pathway • termination of G-protein coupled receptor signaling pathway • positive regulation of GTPase activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6003	246709
Ensembl	ENSG00000127074	ENSMUSG00000051079
UniProt	O14921	Q8K443
RefSeq (mRNA)	NM_002927	NM_153171
RefSeq (protein)	NP_002918	NP_694811
Location (UCSC)	Chr 1: 192.64 – 192.66 Mb	Chr 1: 144.14 – 144.18 Mb
PubMed search

Regulator of G-protein signaling 13 is a protein that in humans is encoded by the RGS13 gene.^[1][2]

RGS 13 is a member of R4 subfamily of RGS (Regulators of G Protein Signaling) proteins which have only short peptide sequences flanking the RGS domain. RGS 13 suppresses the immunoglobulin E- mediated allergic responses.^[3]

The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist.^[2]

References

1. Johnson EN, Druey KM (May 2002). "Functional characterization of the G protein regulator RGS13". J Biol Chem 277 (19): 16768–16774. doi:10.1074/jbc.M200751200. PMID 11875076.
2. "Entrez Gene: RGS13 regulator of G-protein signalling 13".
3. Bansal G, Xie Z, Rao S, Nocka KH, Druey KM (2008). "Suppression of immunoglobulin E-mediated allergic responses by regulator of G protein signaling 13". Nat. Immunol. 9 (1): 73–80. doi:10.1038/ni1533. PMC 2387203. PMID 18026105.

Further reading

• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–321. doi:10.1038/nature04727. PMID 16710414.
• Han JI, Huang NN, Kim DU, Kehrl JH (2006). "RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization". J. Leukoc. Biol. 79 (6): 1357–1368. doi:10.1189/jlb.1105693. PMID 16565322.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Islam TC, Asplund AC, Lindvall JM, et al. (2003). "High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma". Leukemia 17 (9): 1880–1890. doi:10.1038/sj.leu.2403057. PMID 12970790.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Sierra DA, Gilbert DJ, Householder D, et al. (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics 79 (2): 177–185. doi:10.1006/geno.2002.6693. PMID 11829488.
• Druey KM, Blumer KJ, Kang VH, Kehrl JH (1996). "Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family". Nature 379 (6567): 742–746. doi:10.1038/379742a0. PMID 8602223.