RHOJ
| Ras homolog family member J | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | RHOJ ; ARHJ; RASL7B; TC10B; TCL | ||||||||||||
| External IDs | OMIM: 607653 MGI: 1931551 HomoloGene: 56894 GeneCards: RHOJ Gene | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 57381 | 80837 | |||||||||||
| Ensembl | ENSG00000126785 | ENSMUSG00000046768 | |||||||||||
| UniProt | Q9H4E5 | Q9ER71 | |||||||||||
| RefSeq (mRNA) | NM_020663 | NM_023275 | |||||||||||
| RefSeq (protein) | NP_065714 | NP_075764 | |||||||||||
| Location (UCSC) |
Chr 14: 63.2 – 63.29 Mb |
Chr 12: 75.31 – 75.4 Mb | |||||||||||
| PubMed search | |||||||||||||
Rho-related GTP-binding protein RhoJ is a protein that in humans is encoded by the RHOJ gene.[1][2]
ARHJ belongs to the Rho family of small GTP-binding proteins. Rho proteins regulate the dynamic assembly of cytoskeletal components for several physiologic processes, such as cell proliferation and motility and the establishment of cell polarity. They are also involved in pathophysiologic process, such as cell transformation and metastasis.[supplied by OMIM][2]
References
- ↑ Vignal E, De Toledo M, Comunale F, Ladopoulou A, Gauthier-Rouviere C, Blangy A, Fort P (Dec 2000). "Characterization of TCL, a new GTPase of the rho family related to TC10 andCcdc42". J Biol Chem 275 (46): 36457–64. doi:10.1074/jbc.M003487200. PMID 10967094.
- 1 2 "Entrez Gene: RHOJ ras homolog gene family, member J".
Further reading
- Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
- Nishikimi A, Meller N, Uekawa N, et al. (2005). "Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes". FEBS Lett. 579 (5): 1039–46. doi:10.1016/j.febslet.2005.01.006. PMID 15710388.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ruusala A, Aspenström P (2004). "Isolation and characterisation of DOCK8, a member of the DOCK180-related regulators of cell morphology". FEBS Lett. 572 (1–3): 159–66. doi:10.1016/j.febslet.2004.06.095. PMID 15304341.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- de Toledo M, Senic-Matuglia F, Salamero J, et al. (2004). "The GTP/GDP Cycling of Rho GTPase TCL Is an Essential Regulator of the Early Endocytic Pathway". Mol. Biol. Cell 14 (12): 4846–56. doi:10.1091/mbc.E03-04-0254. PMC 284789. PMID 12960428.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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