RIC3

RIC3 acetylcholine receptor chaperone
Identifiers
Symbols	RIC3 ; AYST720; PRO1385
External IDs	OMIM: 610509 MGI: 2443887 HomoloGene: 49772 GeneCards: RIC3 Gene
Gene ontology Molecular function • acetylcholine receptor binding • protein binding involved in protein folding Cellular component • Golgi membrane • endoplasmic reticulum membrane • cytosol • integral component of membrane • neuron projection • neuronal cell body • intracellular membrane-bounded organelle Biological process • protein folding • positive regulation of cytosolic calcium ion concentration • synaptic transmission, cholinergic • protein localization to cell surface • cellular protein complex assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	79608	320360
Ensembl	ENSG00000166405	ENSMUSG00000048330
UniProt	Q7Z5B4	Q8BPM6
RefSeq (mRNA)	NM_001135109	NM_001038624
RefSeq (protein)	NP_001128581	NP_001033713
Location (UCSC)	Chr 11: 8.11 – 8.17 Mb	Chr 7: 109.03 – 109.08 Mb
PubMed search

RIC-3 also known as resistance to inhibitors of cholinesterase 3 is a chaperone protein that in humans is encoded by the RIC3 gene. The RIC3 gene was first discovered in C. elegans.^[1] RIC-3 protein is conserved in most animals and influences the maturation of various ligand gated ion channels including the serotonin 5-HT₃ receptor and nicotinic acetylcholine receptors,^[2][3] particularly the homomeric α₇ nicotinic receptor. RIC-3 enhances currents generated by these receptors by expediting receptor transport to the cell surface and by increasing receptor number.^[4]

References

1. Nguyen M, Alfonso A, Johnson CD, Rand JB (Jun 1995). "Caenorhabditis elegans mutants resistant to inhibitors of acetylcholinesterase". Genetics 140 (2): 527–35. PMID 7498734.
2. Halevi S, Yassin L, Eshel M, Sala F, Sala S, Criado M, Treinin M (Sep 2003). "Conservation within the RIC-3 gene family. Effectors of mammalian nicotinic acetylcholine receptor expression". J Biol Chem 278 (36): 34411–7. doi:10.1074/jbc.M300170200. PMID 12821669.
3. "Entrez Gene: RIC3 resistance to inhibitors of cholinesterase 3 homolog (C. elegans)".
4. Williams ME, Burton B, Urrutia A, et al. (2005). "Ric-3 promotes functional expression of the nicotinic acetylcholine receptor alpha7 subunit in mammalian cells". J. Biol. Chem. 280 (2): 1257–63. doi:10.1074/jbc.M410039200. PMID 15504725.

Further reading

• Cheng A, Bollan KA, Greenwood SM, et al. (2007). "Differential subcellular localization of RIC-3 isoforms and their role in determining 5-HT3 receptor composition.". J. Biol. Chem. 282 (36): 26158–66. doi:10.1074/jbc.M703899200. PMID 17609200.
• Castillo M, Mulet J, Gutiérrez LM, et al. (2007). "Role of the RIC-3 protein in trafficking of serotonin and nicotinic acetylcholine receptors.". J. Mol. Neurosci. 30 (1–2): 153–6. doi:10.1385/JMN:30:1:153. PMID 17192664.
• Lansdell SJ, Gee VJ, Harkness PC, et al. (2005). "RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells". Mol. Pharmacol. 68 (5): 1431–8. doi:10.1124/mol.105.017459. PMID 16120769.
• Castillo M, Mulet J, Gutiérrez LM, et al. (2005). "Dual role of the RIC-3 protein in trafficking of serotonin and nicotinic acetylcholine receptors". J. Biol. Chem. 280 (29): 27062–8. doi:10.1074/jbc.M503746200. PMID 15927954.
• Cheng A, McDonald NA, Connolly CN (2005). "Cell surface expression of 5-hydroxytryptamine type 3 receptors is promoted by RIC-3". J. Biol. Chem. 280 (23): 22502–7. doi:10.1074/jbc.M414341200. PMID 15809299.
• Bennett HM, Lees K, et al. (2012). "Xenopus laevis RIC-3 enhances the functional expression of the C. elegans homomeric nicotinic receptor, ACR-16, in Xenopus oocytes". J. Neurochem. 123 (6): 911–8. doi:10.1111/jnc.12013. PMID 22970690.
• Koperniak TM, Garg BK, et al. (2013). "Cell-specific effects on surface α7 nicotinic receptor expression revealed by over-expression and knockdown of rat RIC3 protein". J. Neurochem. 124 (3): 300–9. doi:10.1111/jnc.12095. PMID 23157401.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.