RILP (gene)

Rab interacting lysosomal protein
PDB rendering based on 1yhn.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1YHN​
Identifiers
Symbols	RILP ; PP10141
External IDs	OMIM: 607848 MGI: 2144271 HomoloGene: 19596 GeneCards: RILP Gene
Gene ontology Molecular function • protein binding • Rab GTPase binding Cellular component • mitochondrion • lysosome • lysosomal membrane • late endosome • phagocytic vesicle membrane • late endosome membrane • protein complex Biological process • endosome to lysosome transport • regulation of multivesicular body size • protein transport • antigen processing and presentation of exogenous peptide antigen via MHC class II • endosome transport via multivesicular body sorting pathway • negative regulation of protein catabolic process • early endosome to late endosome transport • positive regulation of protein catabolic process • intralumenal vesicle formation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	83547	280408
Ensembl	ENSG00000167705	ENSMUSG00000038195
UniProt	Q96NA2	Q5ND29
RefSeq (mRNA)	NM_031430	NM_001029938
RefSeq (protein)	NP_113618	NP_001025109
Location (UCSC)	Chr 17: 1.65 – 1.65 Mb	Chr 11: 75.51 – 75.51 Mb
PubMed search

Rab-interacting lysosomal protein is a protein that in humans is encoded by the RILP gene.^[1][2]

Function

RILP, along with the GTPase RAB7 (MIM 602298), controls late endocytic transport.[supplied by OMIM]^[2]

Interactions

RILP (gene) has been shown to interact with RAB7A.^[1][3]

References

1. Cantalupo G, Alifano P, Roberti V, Bruni CB, Bucci C (February 2001). "Rab-interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes". EMBO J 20 (4): 683–93. doi:10.1093/emboj/20.4.683. PMC 145419. PMID 11179213.
2. "Entrez Gene: RILP Rab interacting lysosomal protein".
3. Caplan S, Hartnell LM, Aguilar RC, Naslavsky N, Bonifacino JS (July 2001). "Human Vam6p promotes lysosome clustering and fusion in vivo". J. Cell Biol. 154 (1): 109–22. doi:10.1083/jcb.200102142. PMC 2196876. PMID 11448994.

Further reading

• Bucci C, De Gregorio L, Bruni CB (2001). "Expression analysis and chromosomal assignment of PRA1 and RILP genes". Biochem. Biophys. Res. Commun. 286 (4): 815–9. doi:10.1006/bbrc.2001.5466. PMID 11520070.
• Jordens I, Fernandez-Borja M, Marsman M, Dusseljee S, Janssen L, Calafat J, Janssen H, Wubbolts R, Neefjes J (2002). "The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dynein-dynactin motors". Curr. Biol. 11 (21): 1680–5. doi:10.1016/S0960-9822(01)00531-0. PMID 11696325.
• Wang T, Hong W (2003). "Interorganellar Regulation of Lysosome Positioning by the Golgi Apparatus through Rab34 Interaction with Rab-interacting Lysosomal Protein". Mol. Biol. Cell 13 (12): 4317–32. doi:10.1091/mbc.E02-05-0280. PMC 138636. PMID 12475955.
• Cardoso C, Leventer RJ, Ward HL, Toyo-Oka K, Chung J, Gross A, Martin CL, Allanson J, Pilz DT, Olney AH, Mutchinick OM, Hirotsune S, Wynshaw-Boris A, Dobyns WB, Ledbetter DH (2003). "Refinement of a 400-kb Critical Region Allows Genotypic Differentiation between Isolated Lissencephaly, Miller-Dieker Syndrome, and Other Phenotypes Secondary to Deletions of 17p13.3". Am. J. Hum. Genet. 72 (4): 918–30. doi:10.1086/374320. PMC 1180354. PMID 12621583.
• Harrison RE, Bucci C, Vieira OV, Schroer TA, Grinstein S (2003). "Phagosomes Fuse with Late Endosomes and/or Lysosomes by Extension of Membrane Protrusions along Microtubules: Role of Rab7 and RILP". Mol. Cell. Biol. 23 (18): 6494–506. doi:10.1128/MCB.23.18.6494-6506.2003. PMC 193691. PMID 12944476.
• Wang T, Wong KK, Hong W (2004). "A Unique Region of RILP Distinguishes It from Its Related Proteins in Its Regulation of Lysosomal Morphology and Interaction with Rab7 and Rab34". Mol. Biol. Cell 15 (2): 815–26. doi:10.1091/mbc.E03-06-0413. PMC 329395. PMID 14668488.
• Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Wu M, Wang T, Loh E, Hong W, Song H (2005). "Structural basis for recruitment of RILP by small GTPase Rab7". EMBO J. 24 (8): 1491–501. doi:10.1038/sj.emboj.7600643. PMC 1142575. PMID 15933719.
• Colucci AM, Campana MC, Bellopede M, Bucci C (2005). "The Rab-interacting lysosomal protein, a Rab7 and Rab34 effector, is capable of self-interaction". Biochem. Biophys. Res. Commun. 334 (1): 128–33. doi:10.1016/j.bbrc.2005.06.067. PMID 15996637.
• Shimojo M, Hersh LB (2006). "Characterization of the REST/NRSF-interacting LIM domain protein (RILP): localization and interaction with REST/NRSF". J. Neurochem. 96 (4): 1130–8. doi:10.1111/j.1471-4159.2005.03608.x. PMID 16417580.
• Marsman M, Jordens I, Rocha N, Kuijl C, Janssen L, Neefjes J (2006). "A splice variant of RILP induces lysosomal clustering independent of dynein recruitment". Biochem. Biophys. Res. Commun. 344 (3): 747–56. doi:10.1016/j.bbrc.2006.03.178. PMID 16631113.
• Progida C, Spinosa MR, De Luca A, Bucci C (2006). "RILP interacts with the VPS22 component of the ESCRT-II complex". Biochem. Biophys. Res. Commun. 347 (4): 1074–9. doi:10.1016/j.bbrc.2006.07.007. PMID 16857164.