RIMS2

Regulating synaptic membrane exocytosis 2
PDB rendering based on 1v27.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1V27​, 1WFG​
Identifiers
Symbols	RIMS2 ; OBOE; RAB3IP3; RIM2
External IDs	OMIM: 606630 HomoloGene: 81639 GeneCards: RIMS2 Gene
Gene ontology Molecular function • protein binding • Rab GTPase binding • ion channel binding • metal ion binding Cellular component • intracellular • cell junction • presynaptic membrane • presynaptic active zone • extracellular exosome Biological process • intracellular protein transport • positive regulation of gene expression • calcium ion-dependent exocytosis • regulation of exocytosis • cAMP-mediated signaling • insulin secretion • regulation of membrane potential • calcium ion-dependent exocytosis of neurotransmitter • spontaneous neurotransmitter secretion • positive regulation of inhibitory postsynaptic potential • positive regulation of dendrite extension • positive regulation of excitatory postsynaptic potential Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9699	116838
Ensembl	ENSG00000176406	ENSMUSG00000037386
UniProt	Q9UQ26	Q9EQZ7
RefSeq (mRNA)	NM_001100117	NM_001256382
RefSeq (protein)	NP_001093587	NP_001243311
Location (UCSC)	Chr 8: 103.5 – 104.26 Mb	Chr 15: 39.2 – 39.68 Mb
PubMed search

Regulating synaptic membrane exocytosis protein 2 is a protein that in humans is encoded by the RIMS2 gene.^[1][2][3]

Interactions

RIMS2 has been shown to interact with YWHAH,^[4] RAPGEF4,^[5][6] and UNC13A.^[7]

References

1. Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (April 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
2. Fukuda M (April 2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". J Biol Chem 278 (17): 15373–80. doi:10.1074/jbc.M212341200. PMID 12578829.
3. "Entrez Gene: RIMS2 regulating synaptic membrane exocytosis 2".
4. Sun, Lei; Bittner Mary A; Holz Ronald W (October 2003). "Rim, a component of the presynaptic active zone and modulator of exocytosis, binds 14-3-3 through its N terminus". J. Biol. Chem. (United States) 278 (40): 38301–9. doi:10.1074/jbc.M212801200. ISSN 0021-9258. PMID 12871946.
5. Shibasaki, Tadao; Sunaga Yasuhiro; Fujimoto Kei; Kashima Yasushige; Seino Susumu (February 2004). "Interaction of ATP sensor, cAMP sensor, Ca2+ sensor, and voltage-dependent Ca2+ channel in insulin granule exocytosis". J. Biol. Chem. (United States) 279 (9): 7956–61. doi:10.1074/jbc.M309068200. ISSN 0021-9258. PMID 14660679.
6. Kashima, Y; Miki T; Shibasaki T; Ozaki N; Miyazaki M; Yano H; Seino S (Dec 2001). "Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion". J. Biol. Chem. (United States) 276 (49): 46046–53. doi:10.1074/jbc.M108378200. ISSN 0021-9258. PMID 11598134.
7. "Protein unc-13 homolog A". UniProt.

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Fenster SD, Chung WJ, Zhai R, et al. (2000). "Piccolo, a presynaptic zinc finger protein structurally related to bassoon.". Neuron 25 (1): 203–14. doi:10.1016/S0896-6273(00)80883-1. PMID 10707984.
• Kashima Y, Miki T, Shibasaki T, et al. (2002). "Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion.". J. Biol. Chem. 276 (49): 46046–53. doi:10.1074/jbc.M108378200. PMID 11598134.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wang Y, Südhof TC (2003). "Genomic definition of RIM proteins: evolutionary amplification of a family of synaptic regulatory proteins( small star, filled ).". Genomics 81 (2): 126–37. doi:10.1016/S0888-7543(02)00024-1. PMID 12620390.
• Sun L, Bittner MA, Holz RW (2003). "Rim, a component of the presynaptic active zone and modulator of exocytosis, binds 14-3-3 through its N terminus.". J. Biol. Chem. 278 (40): 38301–9. doi:10.1074/jbc.M212801200. PMID 12871946.
• Shibasaki T, Sunaga Y, Fujimoto K, et al. (2004). "Interaction of ATP sensor, cAMP sensor, Ca2+ sensor, and voltage-dependent Ca2+ channel in insulin granule exocytosis.". J. Biol. Chem. 279 (9): 7956–61. doi:10.1074/jbc.M309068200. PMID 14660679.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gérard HC, Whittum-Hudson JA, Schumacher HR, Hudson AP (2006). "Synovial Chlamydia trachomatis up regulates expression of a panel of genes similar to that transcribed by Mycobacterium tuberculosis during persistent infection.". Ann. Rheum. Dis. 65 (3): 321–7. doi:10.1136/ard.2005.042226. PMC 1798071. PMID 16192289.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.