RIPK5

Dual serine/threonine and tyrosine protein kinase
Identifiers
Symbols	DSTYK ; CAKUT1; DustyPK; HDCMD38P; RIP5; RIPK5
External IDs	OMIM: 612666 MGI: 1925064 HomoloGene: 19711 GeneCards: DSTYK Gene
EC number	2.7.12.1
Gene ontology Molecular function • protein serine/threonine kinase activity • protein serine/threonine/tyrosine kinase activity • protein tyrosine kinase activity • ATP binding Cellular component • cytoplasm • basolateral plasma membrane • apical plasma membrane • cell junction Biological process • peptidyl-tyrosine phosphorylation • positive regulation of kinase activity • cellular response to fibroblast growth factor stimulus • positive regulation of fibroblast growth factor receptor signaling pathway • positive regulation of ERK1 and ERK2 cascade Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	25778	213452
Ensembl	ENSG00000133059	ENSMUSG00000042046
UniProt	Q6XUX3	Q6XUX1
RefSeq (mRNA)	NM_015375	NM_172516
RefSeq (protein)	NP_056190	NP_766104
Location (UCSC)	Chr 1: 205.14 – 205.21 Mb	Chr 1: 132.42 – 132.47 Mb
PubMed search

Dual serine/threonine and tyrosine protein kinase is an enzyme that in humans is encoded by the DSTYK gene.^[1][2]

This gene encodes a dual serine/threonine and tyrosine protein kinase which is expressed in multiple tissues. Multiple alternatively spliced transcript variants have been found, but the biological validity of some variants has not been determined.^[2]

In melanocytic cells RIPK5 gene expression may be regulated by MITF.^[3]

References

1. Zha J, Zhou Q, Xu LG, Chen D, Li L, Zhai Z, Shu HB (Jun 2004). "RIP5 is a RIP-homologous inducer of cell death". Biochem Biophys Res Commun 319 (2): 298–303. doi:10.1016/j.bbrc.2004.04.194. PMID 15178406.
2. "Entrez Gene: RIPK5 receptor interacting protein kinase 5".
3. Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

Further reading

• Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Seki N, Ohira M, Nagase T, et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Peng J, Dong W, Chen Y, et al. (2007). "Dusty protein kinases: primary structure, gene evolution, tissue specific expression and unique features of the catalytic domain". Biochim. Biophys. Acta 1759 (11–12): 562–72. doi:10.1016/j.bbaexp.2006.10.004. PMID 17123648.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.