RIT2

Ras-like without CAAX 2
Identifiers
Symbols	RIT2 ; RIBA; RIN; ROC2
External IDs	OMIM: 609592 MGI: 108054 HomoloGene: 2198 GeneCards: RIT2 Gene
Gene ontology Molecular function • GTPase activity • calmodulin binding • GTP binding Cellular component • nucleus • plasma membrane Biological process • signal transduction • small GTPase mediated signal transduction • synaptic transmission • neurotrophin TRK receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6014	19762
Ensembl	ENSG00000152214	ENSMUSG00000057455
UniProt	Q99578	P70425
RefSeq (mRNA)	NM_001272077	NM_009065
RefSeq (protein)	NP_001259006	NP_033091
Location (UCSC)	Chr 18: 42.74 – 43.12 Mb	Chr 18: 30.97 – 31.32 Mb
PubMed search

GTP-binding protein Rit2 is a protein that in humans is encoded by the RIT2 gene.^[1][2][3]

RIN belongs to the RAS (HRAS; MIM 190020) superfamily of small GTPases (Shao et al., 1999).[supplied by OMIM]^[3]

RIT2 has been associated with Parkinson's disease in two large genetic studies.^[4][5] An gene expression study of postmortem brain has suggested RIT2 interacts with interferon-γ signalling.^[6]

Interactions

RIT2 has been shown to interact with POU4F1.^[7]

References

1. Lee CH, Della NG, Chew CE, Zack DJ (Nov 1996). "Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins". J Neurosci 16 (21): 6784–94. PMID 8824319.
2. Wes PD, Yu M, Montell C (Jan 1997). "RIC, a calmodulin-binding Ras-like GTPase". EMBO J 15 (21): 5839–48. PMC 452332. PMID 8918462.
3. "Entrez Gene: RIT2 Ras-like without CAAX 2".
4. Pankratz, N; Beecham, G. W.; Destefano, A. L.; Dawson, T. M.; Doheny, K. F.; Factor, S. A.; Hamza, T. H.; Hung, A. Y.; Hyman, B. T.; Ivinson, A. J.; Krainc, D; Latourelle, J. C.; Clark, L. N.; Marder, K; Martin, E. R.; Mayeux, R; Ross, O. A.; Scherzer, C. R.; Simon, D. K.; Tanner, C; Vance, J. M.; Wszolek, Z. K.; Zabetian, C. P.; Myers, R. H.; Payami, H; Scott, W. K.; Foroud, T; Pd Gwas, Consortium (2012). "Meta-analysis of Parkinson's disease: Identification of a novel locus, RIT2". Annals of Neurology 71 (3): 370–84. doi:10.1002/ana.22687. PMC 3354734. PMID 22451204.
5. Nalls, M. A.; Pankratz, N; Lill, C. M.; Do, C. B.; Hernandez, D. G.; Saad, M; Destefano, A. L.; Kara, E; Bras, J; Sharma, M; Schulte, C; Keller, M. F.; Arepalli, S; Letson, C; Edsall, C; Stefansson, H; Liu, X; Pliner, H; Lee, J. H.; Cheng, R; International Parkinson's Disease Genomics Consortium (IPDGC); Parkinson's Study Group (PSG) Parkinson's Research: The Organized GENetics Initiative (PROGENI); Hadjigeorgiou, Georgios M; Bis, Joshua C; NeuroGenetics Research Consortium (NGRC); Hussman Institute of Human Genomics (HIHG); Ashkenazi Jewish Dataset Investigator; Cohorts for Health Aging Research in Genetic Epidemiology (CHARGE); North American Brain Expression Consortium (NABEC); et al. (2014). "Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease". Nature Genetics 46 (9): 989–93. doi:10.1038/ng.3043. PMC 4146673. PMID 25064009.
6. Liscovitch, N; French, L (2014). "Differential Co-Expression between α-Synuclein and IFN-γ Signaling Genes across Development and in Parkinson's Disease". PLoS ONE 9 (12): e115029. doi:10.1371/journal.pone.0115029. PMC 4262449. PMID 25493648.
7. Calissano, M; Latchman D S (Aug 2003). "Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor". Oncogene (England) 22 (35): 5408–14. doi:10.1038/sj.onc.1206635. ISSN 0950-9232. PMID 12934100.

Further reading

• Shao H, Kadono-Okuda K, Finlin BS, Andres DA (1999). "Biochemical characterization of the Ras-related GTPases Rit and Rin.". Arch. Biochem. Biophys. 371 (2): 207–19. doi:10.1006/abbi.1999.1448. PMID 10545207.
• Hoshino M, Nakamura S (2002). "The Ras-like small GTP-binding protein Rin is activated by growth factor stimulation.". Biochem. Biophys. Res. Commun. 295 (3): 651–6. doi:10.1016/S0006-291X(02)00731-3. PMID 12099688.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Calissano M, Latchman DS (2003). "Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor.". Oncogene 22 (35): 5408–14. doi:10.1038/sj.onc.1206635. PMID 12934100.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hartwig C, Veske A, Krejcova S, et al. (2006). "Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin.". BMC neuroscience 6: 53. doi:10.1186/1471-2202-6-53. PMC 1215486. PMID 16122393.
• Shi GX, Han J, Andres DA (2006). "Rin GTPase couples nerve growth factor signaling to p38 and b-Raf/ERK pathways to promote neuronal differentiation.". J. Biol. Chem. 280 (45): 37599–609. doi:10.1074/jbc.M507364200. PMID 16157584.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.