RNA ligase (ATP)

RNA ligase (ATP)
Identifiers
EC number 6.5.1.3
CAS number 37353-39-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, an RNA ligase (ATP) (EC 6.5.1.3) is an enzyme that catalyzes the chemical reaction

ATP + (ribonucleotide)n + (ribonucleotide)m \rightleftharpoons AMP + diphosphate + (ribonucleotide)n+m

The 3 substrates of this enzyme are ATP, (ribonucleotide)n, and (ribonucleotide)m, whereas its 3 products are AMP, diphosphate, and (ribonucleotide)n+m.

This enzyme belongs to the family of ligases, specifically those forming phosphoric-ester bonds. The systematic name of this enzyme class is poly(ribonucleotide):poly(ribonucleotide) ligase (AMP-forming). Other names in common use include polyribonucleotide synthase (ATP), RNA ligase, polyribonucleotide ligase, and ribonucleic ligase.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1VDX and 2C5U.

References

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