RNF135

Ring finger protein 135
Identifiers
Symbols	RNF135 ; L13; MMFD; REUL; Riplet
External IDs	OMIM: 611358 MGI: 1919206 HomoloGene: 12427 GeneCards: RNF135 Gene
Gene ontology Molecular function • ubiquitin-protein transferase activity • protein binding • zinc ion binding • ligase activity • ribonucleoprotein complex binding Cellular component • cytoplasm • cytosol Biological process • protein ubiquitination • negative regulation of type I interferon production • positive regulation of interferon-beta production • innate immune response • regulation of innate immune response Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84282	71956
Ensembl	ENSG00000181481	ENSMUSG00000020707
UniProt	Q8IUD6	Q9CWS1
RefSeq (mRNA)	NM_001184992	NM_028019
RefSeq (protein)	NP_001171921	NP_082295
Location (UCSC)	Chr 17: 30.97 – 31 Mb	Chr 11: 80.18 – 80.2 Mb
PubMed search

RING finger protein 135 is a protein that in humans is encoded by the RNF135 gene.^[1][2][3]

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.^[3]

Interactions

RNF135 has been shown to interact with RARRES3.^[2]

References

1. Jenne DE, Tinschert S, Reimann H, Lasinger W, Thiel G, Hameister H, Kehrer-Sawatzki H (Aug 2001). "Molecular characterization and gene content of breakpoint boundaries in patients with neurofibromatosis type 1 with 17q11.2 microdeletions". Am J Hum Genet 69 (3): 516–27. doi:10.1086/323043. PMC 1235482. PMID 11468690.
2. Oshiumi H, Matsumoto M, Hatakeyama S, Seya T (Jan 2009). "Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection". J Biol Chem 284 (2): 807–17. doi:10.1074/jbc.M804259200. PMID 19017631.
3. "Entrez Gene: RNF135 ring finger protein 135".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Jenne DE, Tinschert S, Dorschner MO, et al. (2003). "Complete physical map and gene content of the human NF1 tumor suppressor region in human and mouse.". Genes Chromosomes Cancer 37 (2): 111–20. doi:10.1002/gcc.10206. PMID 12696059.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Petroziello J, Yamane A, Westendorf L, et al. (2004). "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer.". Oncogene 23 (46): 7734–45. doi:10.1038/sj.onc.1207921. PMID 15334068.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Douglas J, Cilliers D, Coleman K, et al. (2007). "Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth.". Nat. Genet. 39 (8): 963–5. doi:10.1038/ng2083. PMID 17632510.