RNF139

Ring finger protein 139
Identifiers
Symbols	RNF139 ; HRCA1; RCA1; TRC8
External IDs	OMIM: 603046 MGI: 1923091 HomoloGene: 5222 GeneCards: RNF139 Gene
Gene ontology Molecular function • protease binding • ubiquitin-protein transferase activity • receptor activity • protein binding • zinc ion binding • ligase activity • ubiquitin-like protein transferase activity Cellular component • endoplasmic reticulum • integral component of membrane • Derlin-1 retrotranslocation complex Biological process • negative regulation of cell proliferation • protein ubiquitination • negative regulation of translation • regulation of protein ubiquitination • protein destabilization • ERAD pathway • regulation of ER to Golgi vesicle-mediated transport • regulation of protein processing • positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11236	75841
Ensembl	ENSG00000170881	ENSMUSG00000037075
UniProt	Q8WU17	Q7TMV1
RefSeq (mRNA)	NM_007218	NM_175226
RefSeq (protein)	NP_009149	NP_780435
Location (UCSC)	Chr 8: 124.47 – 124.49 Mb	Chr 15: 58.89 – 58.9 Mb
PubMed search

RING finger protein 139 is a protein that in humans is encoded by the RNF139 gene.^[1][2]

The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP.^[2]

References

1. Gemmill RM, West JD, Boldog F, Tanaka N, Robinson LJ, Smith DI, Li F, Drabkin HA (Sep 1998). "The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8". Proc Natl Acad Sci U S A 95 (16): 9572–7. doi:10.1073/pnas.95.16.9572. PMC 21380. PMID 9689122.
2. "Entrez Gene: RNF139 ring finger protein 139".

Further reading

• Poland KS, Azim M, Folsom M, et al. (2007). "A constitutional balanced t(3;8)(p14;q24.1) translocation results in disruption of the TRC8 gene and predisposition to clear cell renal cell carcinoma.". Genes Chromosomes Cancer 46 (9): 805–12. doi:10.1002/gcc.20466. PMID 17539022.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Brauweiler A, Lorick KL, Lee JP, et al. (2007). "RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene.". Oncogene 26 (16): 2263–71. doi:10.1038/sj.onc.1210017. PMID 17016439.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gemmill RM, Bemis LT, Lee JP, et al. (2002). "The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway.". Oncogene 21 (22): 3507–16. doi:10.1038/sj.onc.1205437. PMID 12032852.
• Lorick KL, Jensen JP, Fang S, et al. (1999). "RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination.". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11364–9. doi:10.1073/pnas.96.20.11364. PMC 18039. PMID 10500182.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.