RNF7

Ring finger protein 7
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols RNF7 ; CKBBP1; ROC2; SAG
External IDs OMIM: 603863 MGI: 1337096 HomoloGene: 84476 GeneCards: RNF7 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 9616 19823
Ensembl ENSG00000114125 ENSMUSG00000051234
UniProt Q9UBF6 Q9WTZ1
RefSeq (mRNA) NM_001201370 NM_011279
RefSeq (protein) NP_001188299 NP_035409
Location (UCSC) Chr 3:
141.74 – 141.75 Mb
Chr 9:
96.47 – 96.48 Mb
PubMed search

RING-box protein 2 is a protein that in humans is encoded by the RNF7 gene.[1][2][3]

The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported.[3]

Interactions

RNF7 has been shown to interact with CSNK2B.[4]

See also

References

  1. Duan H, Wang Y, Aviram M, Swaroop M, Loo JA, Bian J, Tian Y, Mueller T, Bisgaier CL, Sun Y (April 1999). "SAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agents". Mol Cell Biol 19 (4): 3145–55. PMC 84108. PMID 10082581.
  2. Ohta T, Michel JJ, Schottelius AJ, Xiong Y (May 1999). "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity". Mol Cell 3 (4): 535–41. doi:10.1016/S1097-2765(00)80482-7. PMID 10230407.
  3. 1 2 "Entrez Gene: RNF7 ring finger protein 7".
  4. Ahn, B H; Kim T H; Bae Y S (October 2001). "Mapping of the interaction domain of the protein kinase CKII beta subunit with target proteins". Mol. Cells (Korea (South)) 12 (2): 158–63. ISSN 1016-8478. PMID 11710515.

Further reading

External links


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