ROBO2

Roundabout guidance receptor 2
PDB rendering based on 1uem.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1UEM​, 1UJT​, 2EDJ​
Identifiers
Symbols	ROBO2 ; SAX3
External IDs	OMIM: 602431 MGI: 1890110 HomoloGene: 43188 GeneCards: ROBO2 Gene
Gene ontology Molecular function • protein binding • axon guidance receptor activity • identical protein binding Cellular component • cell surface • integral component of membrane • axolemma • extracellular exosome Biological process • metanephros development • ureteric bud development • homophilic cell adhesion via plasma membrane adhesion molecules • axon guidance • central nervous system development • brain development • axon midline choice point recognition • olfactory bulb interneuron development • retinal ganglion cell axon guidance • cellular response to hormone stimulus • positive regulation of axonogenesis • negative regulation of negative chemotaxis • negative regulation of synapse assembly • apoptotic process involved in luteolysis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6092	268902
Ensembl	ENSG00000185008	ENSMUSG00000052516
UniProt	Q9HCK4	E9PYK2
RefSeq (mRNA)	NM_001128929	NM_175549
RefSeq (protein)	NP_001122401	NP_780758
Location (UCSC)	Chr 3: 75.91 – 77.65 Mb	Chr 16: 73.89 – 74.41 Mb
PubMed search

Roundabout homolog 2 is a protein that in humans is encoded by the ROBO2 gene.^[1][2]

References

1. Kidd T, Brose K, Mitchell KJ, Fetter RD, Tessier-Lavigne M, Goodman CS, Tear G (Feb 1998). "Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors". Cell 92 (2): 205–15. doi:10.1016/S0092-8674(00)80915-0. PMID 9458045.
2. "Entrez Gene: ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila)".

Further reading

• Brose K, Bland KS, Wang KH, et al. (1999). "Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance.". Cell 96 (6): 795–806. doi:10.1016/S0092-8674(00)80590-5. PMID 10102268.
• Nguyen Ba-Charvet KT, Brose K, Marillat V, et al. (1999). "Slit2-Mediated chemorepulsion and collapse of developing forebrain axons.". Neuron 22 (3): 463–73. doi:10.1016/S0896-6273(00)80702-3. PMID 10197527.
• Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
• Nguyen Ba-Charvet KT, Brose K, Ma L, et al. (2001). "Diversity and specificity of actions of Slit2 proteolytic fragments in axon guidance.". J. Neurosci. 21 (12): 4281–9. PMID 11404413.
• Marillat V, Cases O, Nguyen-Ba-Charvet KT, et al. (2002). "Spatiotemporal expression patterns of slit and robo genes in the rat brain.". J. Comp. Neurol. 442 (2): 130–55. doi:10.1002/cne.10068. PMID 11754167.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hivert B, Liu Z, Chuang CY, et al. (2003). "Robo1 and Robo2 are homophilic binding molecules that promote axonal growth.". Mol. Cell. Neurosci. 21 (4): 534–45. doi:10.1006/mcne.2002.1193. PMID 12504588.
• Grieshammer U, Le Ma , Plump AS; et al. (2004). "SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site.". Dev. Cell 6 (5): 709–17. doi:10.1016/S1534-5807(04)00108-X. PMID 15130495.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yue Y, Grossmann B, Galetzka D, et al. (2007). "Isolation and differential expression of two isoforms of the ROBO2/Robo2 axon guidance receptor gene in humans and mice.". Genomics 88 (6): 772–8. doi:10.1016/j.ygeno.2006.05.011. PMID 16829019.
• Lu W, van Eerde AM, Fan X, et al. (2007). "Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux.". Am. J. Hum. Genet. 80 (4): 616–32. doi:10.1086/512735. PMC 1852714. PMID 17357069.