ROBO3

Roundabout guidance receptor 3
Identifiers
Symbols	ROBO3 ; HGPPS; HGPS; RBIG1; RIG1
External IDs	OMIM: 608630 MGI: 1343102 HomoloGene: 32119 GeneCards: ROBO3 Gene
Gene ontology Molecular function • protein homodimerization activity • protein heterodimerization activity Cellular component • integral component of membrane • axon Biological process • neuron migration • axon guidance • axon midline choice point recognition • chemoattraction of axon • chemorepulsion of axon • commissural neuron axon guidance Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	64221	19649
Ensembl	ENSG00000154134	ENSMUSG00000032128
UniProt	Q96MS0	D3Z4M6
RefSeq (mRNA)	NM_022370	NM_001164767
RefSeq (protein)	NP_071765	NP_001158239
Location (UCSC)	Chr 11: 124.87 – 124.88 Mb	Chr 9: 37.42 – 37.43 Mb
PubMed search

Roundabout homolog 3 is a protein that in humans is encoded by the ROBO3 gene.^[1][2]

References

1. Jen JC, Chan WM, Bosley TM, Wan J, Carr JR, Rub U, Shattuck D, Salamon G, Kudo LC, Ou J, Lin DD, Salih MA, Kansu T, Al Dhalaan H, Al Zayed Z, MacDonald DB, Stigsby B, Plaitakis A, Dretakis EK, Gottlob I, Pieh C, Traboulsi EI, Wang Q, Wang L, Andrews C, Yamada K, Demer JL, Karim S, Alger JR, Geschwind DH, Deller T, Sicotte NL, Nelson SF, Baloh RW, Engle EC (Jun 2004). "Mutations in a human ROBO gene disrupt hindbrain axon pathway crossing and morphogenesis". Science 304 (5676): 1509–13. doi:10.1126/science.1096437. PMC 1618874. PMID 15105459.
2. "Entrez Gene: ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Yuan SS, Cox LA, Dasika GK, Lee EY (1999). "Cloning and functional studies of a novel gene aberrantly expressed in RB-deficient embryos.". Dev. Biol. 207 (1): 62–75. doi:10.1006/dbio.1998.9141. PMID 10049565.
• Jen J, Coulin CJ, Bosley TM, et al. (2002). "Familial horizontal gaze palsy with progressive scoliosis maps to chromosome 11q23-25.". Neurology 59 (3): 432–5. doi:10.1212/wnl.59.3.432. PMID 12177379.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bosley TM, Salih MA, Jen JC, et al. (2006). "Neurologic features of horizontal gaze palsy and progressive scoliosis with mutations in ROBO3.". Neurology 64 (7): 1196–203. doi:10.1212/01.WNL.0000156349.01765.2B. PMID 15824346.
• Camurri L, Mambetisaeva E, Davies D, et al. (2006). "Evidence for the existence of two Robo3 isoforms with divergent biochemical properties.". Mol. Cell. Neurosci. 30 (4): 485–93. doi:10.1016/j.mcn.2005.07.014. PMID 16226035.
• Chan WM, Traboulsi EI, Arthur B, et al. (2006). "Horizontal gaze palsy with progressive scoliosis can result from compound heterozygous mutations in ROBO3.". J. Med. Genet. 43 (3): e11. doi:10.1136/jmg.2005.035436. PMC 2563249. PMID 16525029.