ROBO4
| Roundabout guidance receptor 4 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | ROBO4 ; ECSM4; MRB | ||||||||||||
| External IDs | OMIM: 607528 MGI: 1921394 HomoloGene: 10397 GeneCards: ROBO4 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 54538 | 74144 | |||||||||||
| Ensembl | ENSG00000154133 | ENSMUSG00000032125 | |||||||||||
| UniProt | Q8WZ75 | Q8C310 | |||||||||||
| RefSeq (mRNA) | NM_001301088 | NM_001309390 | |||||||||||
| RefSeq (protein) | NP_001288017 | NP_001296319 | |||||||||||
| Location (UCSC) |
Chr 11: 124.88 – 124.9 Mb |
Chr 9: 37.4 – 37.41 Mb | |||||||||||
| PubMed search | |||||||||||||
Roundabout homolog 4 is a protein that in humans is encoded by the ROBO4 gene.[1][2]
References
- ↑ Huminiecki L, Bicknell R (Dec 2000). "In silico cloning of novel endothelial-specific genes". Genome Res 10 (11): 1796–1806. doi:10.1101/gr.150700. PMC 310981. PMID 11076864.
- ↑ "Entrez Gene: ROBO4 roundabout homolog 4, magic roundabout (Drosophila)".
Further reading
- Schmucker D (2003). "Downstream of guidance receptors: entering the baroque period of axon guidance signaling". Neuron 40 (1): 4–6. doi:10.1016/S0896-6273(03)00603-2. PMID 14527427.
- Huminiecki L, Gorn M, Suchting S, et al. (2002). "Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesis". Genomics 79 (4): 547–552. doi:10.1006/geno.2002.6745. PMID 11944987.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Park KW, Morrison CM, Sorensen LK, et al. (2003). "Robo4 is a vascular-specific receptor that inhibits endothelial migration". Dev. Biol. 261 (1): 251–267. doi:10.1016/S0012-1606(03)00258-6. PMID 12941633.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Bedell VM, Yeo SY, Park KW, et al. (2005). "roundabout4 is essential for angiogenesis in vivo". Proc. Natl. Acad. Sci. U.S.A. 102 (18): 6373–6378. doi:10.1073/pnas.0408318102. PMC 1088354. PMID 15849270.
- Seth P, Lin Y, Hanai J, et al. (2005). "Magic roundabout, a tumor endothelial marker: expression and signaling". Biochem. Biophys. Res. Commun. 332 (2): 533–541. doi:10.1016/j.bbrc.2005.03.250. PMID 15894287.
- Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–2080. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
- Gröne J, Doebler O, Loddenkemper C, et al. (2007). "Robo1/Robo4: differential expression of angiogenic markers in colorectal cancer". Oncol. Rep. 15 (6): 1437–43. doi:10.3892/or.15.6.1437. PMID 16685377.
- Okada Y, Yano K, Jin E, et al. (2007). "A three-kilobase fragment of the human Robo4 promoter directs cell type-specific expression in endothelium". Circ. Res. 100 (12): 1712–1722. doi:10.1161/01.RES.0000269779.10644.dc. PMID 17495228.
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